[wearily fetches megaphone and points it in the direction of Fleet Street] THE APP IS PINGING BECAUSE EVERYONE HAS THE DISEASE, IT HASN’T GAINED FUCKING SENTIENCE

How can #AI help us speed up scientific discovery? We’ve teamed up with @DeepMind to make #AlphaFold protein structure predictions freely and openly available to the scientific community. ebi.ac.uk/about/news/pre… #FAIRdata #structuralbiology #opendata

While structural biologists are either excited or having existential crisis everywhere thanks to #AlphaFold, I'm here in the corner staring at my protein of interest, that looks like a badly drawn large intestine picture in a biology textbook. I guess, I still have stuff to do.

I’d like to share some helpful tips for new molecular biologists: P10 P20 P200 P1000

Many single protein chains can be accurately predicted using AlphaFold, but multi-chain protein complexes remain challenging. Introducing AlphaFold-Multimer, a model that can predict the structure of multi-chain protein complexes with increased accuracy dpmd.ai/alphafold_mult… 1/

Extraordinary story about why medical orgs like WHO and CDC took so long to acknowledge Covid was airborne (and why handwashing etc was emphasised at the start + not masks etc...) wired.com/story/the-teen…

Ever wondered why the majority of mammalian gene promoters are embedded within CpG islands? Check out this beautiful work by Amy Hughes showing that a protein complex which binds to CGIs protects genes from premature transcription termination! biorxiv.org/content/10.110…

Great to see all of Amy Hughes hard work finally out in the world! This project took several turns we didn't expect but came together into a really interesting story!

Really excited to see some of the work from my PhD in the Rob Klose lab on BioRxiv! Thank you to all of the co-authors and all members of the Klose lab, past and present, for all of the help along the way!

Congrats Amy Hughes! A lot of hard work went into this story and it's very exciting to have the final version out at last!

Excited to see Aleksander Szczurek, @emmy_dimitrova, and Jess Kelley 's paper on bioRxiv. Hope you enjoy this deep dive into Polycomb-mediated transcriptional repression using live single-cell imaging approaches! #polycomb biorxiv.org/content/10.110…

Very exciting to see this work up on bioRxiv! Congratulations Aleksander Szczurek, who has written a short thread explaining the key findings:

Great to see Aleksander Szczurek's paper out today! A wonderful team effort with @emmy_dimitrova , Jess Kelley , and Neil Blackledge. Have a look if you are interested in how #Polycomb controls transcription to repress gene expression. rdcu.be/dTD3t

In our new paper aided by single molecule imaging of RNA and transcription machinery we demonstrate how Polycomb Repressive Complex (PRC) represses transcription in live cells 🧵 nature.com/articles/s4155… 1/9

It has been 10 years since I started doing Western blots in the lab. Wow, what a rollercoaster! Based on my successes and failures, here are some tips for perfect Western blots. A thread (1/5)…

Big shout out to those researchers who made their data available in PDB over the years The Chemistry Nobel Prize winners today relied on that open academic data to train their models We wouldn't have these advances if researchers hadn't made 200,000 protein structures available

I had an amazing time doing my DPhil in Rob's lab - do check out the different programmes on offer and get your applications in!

I'll be over on the other place at jesskelley.bsky.social