We're thrilled to share a new toolkit for mammalian synthetic biology: the COMET library of synthetic transcription factors, promoters, and accompanying models biorxiv.org/cgi/content/sh…

Want to study #synbio w/ Mary Dunlop, Douglas Densmore, #WilsonWong, Dr. Allyson Sgro, Mo Khalil, John Ngo in Boston? Consider BU! We launched the first NIH Biotech PhD Training program in #synbio! Plus great industry partners Ginkgo Bioworks, Moderna, etc. sites.bu.edu/sb2/

The journal "Structure" just let me know that the final version of the "Illustrate" paper is up and ready: authors.elsevier.com/a/1a0R13SNvbug…

BU Biological Design Center is looking for PhD-holding professionals in Boston to mentor students on non-academic careers. All fields are welcome! Interested? Fill out this form shorturl.at/noK02. More info? Contact [email protected], or read our blog shorturl.at/rxG05

Why False Claims About #COVID19 Refuse to Die: Tracking the information zombie apocalypse. buff.ly/34CUDxN Nautilus Magazine

The BDC's Student Program for Industry Networking (BDC SPIN) provides year round mentorship and networking for industry-minded PhD students. Stay up to date with their events, discover mentorship resources, and learn how to join SPIN via their new website: sites.bu.edu/bdcspin

amazing paper. 40-60% of population that have NOT had SARS-CoV-2 already have activated T Cells to the virus! likely due to cross-reactivity w/ other "common cold coronaviruses". may explain large % having easy time clearing virus and/or mild/no symptoms. cell.com/action/showPdf…

A computer model attempts to simulate the metabolic network of a minimal cell with 493 genes elifesciences.org/digests/36842/…

Controlling how cells “feel” and respond mechanical forces through protein engineering. I’m excited to share a preprint version of my graduate work with John Ngo! #synbio

Alzheimer’s Twitter: as a cell biologist I struggle with the AD literature. Now, I’m asking for help. Please DM me with your answer to the following question: how does the ß-amyloid peptide kill a cell and/or produce Alzheimer’s dementia.

Excited to share our latest work in Nature Chemical Biology! Lead author Deivids engineered an ultra-potent Notch ligand, named DeltaMAX, with applications in regenerative medicine and cancer therapy. (1/8) nature.com/articles/s4158…

Finally able to share some of my PhD work! We created a drug inducible toolset to control diverse protein activities, including a single-chain Cre recombinase. The inducers are highly characterized, FDA-approved drugs, and they function in mammalian and prokaryotic contexts.

Nature highlighted a recent John Ngo Lab paper. Check it out! nature BU Engineering #BiologicalDesignCenter nature.com/articles/s4159…

Now online! Structural basis for membrane-proximal proteolysis of substrates by ADAM10 dlvr.it/SstpJ6

Our latest review in Trends in Pharmacological Sciences! We cover recent Notch-based biotech with a focus on T cell therapy & synNotch. Things have really 'stepped up a Notch' (cringe) in the past few years. Great effort from @ElliotMedina31 Daniel Antfolk & David Perez sciencedirect.com/science/articl…

Engineering synthetic agonists for targeted activation of Notch signaling biorxiv.org/cgi/content/sh… #biorxiv_synbio

I don't think that 100 years ago, Otto Warburg was aware how broadly relevant his discovery was. Now excited to publicly share this work led by Hooman Hefzi wherein we engineered the Warburg effect out of mammalian cells to improve biologics production doi.org/10.1101/2024.0…

Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in Escherichia coli biorxiv.org/cgi/content/sh… #biorxiv_synbio

RNA-Stabilized Coat Proteins for Sensitive and Simultaneous Imaging of Distinct Single mRNAs in Live Cells biorxiv.org/cgi/content/sh… #biorxiv_bioeng

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. Djenet Bousbaine led the charge... nature 1/55