🚀Excited to share our latest preprint on the Methylation Screening Array (MSA) design to facilitate human EWAS discoveries. MSA leverages previous EWAS, bulk, single-cell WGBS data, and technologies for ultra-high throughput profiling. Checkout details:
biorxiv.org/cgi/content/sh…

A remarkable epigenetic phenomenon known as genomic imprinting was discovered in 1984.

Anne Ferguson-Smith and Dr. Marisa Bartolomei trace the history of this field and the impact it has had on scientists’ understanding of development, inheritance and disease. go.nature.com/4dySaHA

My latest PhD Project is now up on medRxiv: medrxiv.org/content/10.110… ! Here, we looked at the association between antidepressant exposure and DNA methylation🧬in 16,536 individuals in Generation Scotland. A 🧵 of our main findings:

Is the offspring’s DNA methylome a possible mechanism through which direct and indirect genetic effects act? Yes! In this new Netherlands Twin Register preprint, we found 51 offspring CpGs related to parental or offspring PGSs for schizophrenia, EA, BMI & height. 1/4

Are you interested in #sexdifferences , #placenta and #methylation ? Check out our new paper in CLMS Springer Cell Bio with Binder Lab Sonja Entringer and Jari Lahti from University of Helsinki link.springer.com/article/10.100…

Our paper on epigenetics of diabetes in #twin s is out-
authors.elsevier.com/sd/article/S23…

Great team effort across 7 #twin cohorts!
w Tiphaine Martin Sergio Cervantes Vi Olga Perminder Sachdev Kirsi Pietiläinen Miina Jenny van Dongen Gonneke Willemsen Elin Grundberg Tim Spector MD (Prof) TwinsUK research et al

🎶 Ludwig van Beethoven, one of the most celebrated musicians in human history, has a low genetic predisposition for 'musicality'.

We discuss challenges of polygenic score predictions at the individual level, and for someone who lived over 200 years ago: authors.elsevier.com/sd/article/S09…

Out now, our deep dive into the Illumina #EPICv2 #methylation array - doi.org/mkf7 including enhanced manifest annotation file. Watch this space for imminent #DMRcate updates Bioconductor. Huge thanks to Dr Tim Peters and the team ClarkLab Garvan Institute of Medical Research

Excited to share our new paper on experimental and computational methods for studying #DNAmethylation with Infinium arrays in low-input samples, even single cells! We dived into the nuances of chromatin states and germ cell development. doi.org/10.1093/nar/gk…

The NEW Infinium Methylation Screening Array from Illumina is now available! Highlights:

✅Expert-designed content for epidemiological research
✅ Exceptional affordability & scalability to apply epigenetics to population-scale projects
✅Highly precise DNA methylation data

New preprint by Bodine Gonggrijp
Netherlands Twin Register
Negative Life Events and Epigenetic Ageing: a Study in the Netherlands Twin Register biorxiv.org/content/10.110…

✨🧬Excited to share our latest #MPRGBiosocial pub on self-control, biological aging, and health 🧬✨ 👉doi.org/10.1186/s13148… with Abby deSteiguer Peter Tanksley Deniz Fraemke (@denizfraemke.bsky.social) Philipp Koellinger Elliot Tucker-Drob Kathryn Paige Harden Laurel Raffington, PhD

Our new paper is out in G3: Genes | Genomes | Genetics - comparison of methods to identify genetic variants associated with phenotype variability.

Proud of my PhD student Xiaopu Zhang for leading this work!

Read more to see which methods to use & when:
doi.org/10.1093/g3jour…

Check out these exciting new opportunities! All 4 year positions with amazing colleagues!

New paper by Anna Niehues Fiona Hagenbeek Netherlands Twin Register X-omics
Multi-omics data analysis workflow packaged as a FAIR Digital Object academic.oup.com/gigascience/ar…

New paper! Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins
Netherlands Twin Register X-omics Fiona Hagenbeek Nikki Hubers
bmcmedicine.biomedcentral.com/articles/10.11…

New preprint: Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study
Netherlands Twin Register ayse demirkan
biorxiv.org/content/10.110…

NEWS: Six genes found for a woman's likelihood of having fraternal twins. The results of the research by the Twinning Genetics Consortium and researchers Netherlands Twin Register Vrije Universiteit Amsterdam, are published in the scientific journal Human Reproduction. vu.nl/en/news/2023/s…

It was a great pleasure to give a presentation at the ISTS webinar yesterday together with Bernadette de Bakker from the Dutch Fetal Biobank! We also look forward to the next TWINS Congress in September 2024 Netherlands Twin Register twinscongress.com