📢Unraveling autoimmune queries! Our latest study in Nature Communications introduces the profiling of autoantibody repertoires in #Rheumatoidarthritis with molecular-resolution: Each patient's ACPA IgG1 repertoire is unique and diverse, illuminating the complexity of autoimmune responses

Our paper on the nanoRAPIDS platform is out in Communications Chemistry. The analytical pipeline nanofractionates 10 ul complex culture extract into 384 wells and then determines high-res mass and bioactivity of all peaks.
doi.org/10.1038/s42004…

Anyone interested in applying for MSCA fellowships to join our team at Human Genetics Nijmegen, Radboudumc Radboudumc - for most innovative genomics in rare disease research - attractive support options via us as host. Send DM or email if you qualify and are interested.

radboudumc.nl/en/research/ac…

We just published a new exciting paper on 'Visualization and exploration of linked data using virtual reality'. Great work Alexander Kellmann and MOLGENIS team UMCG Genetica! academic.oup.com/database/artic…

Freely available open access Analytical Chemistry paper on consistency of MS/MS data across instrument manufacturer platforms pubs.acs.org/doi/10.1021/ac…
helps answer the most common question I get regarding MS/MS data. Yes, there is high consistency across QTOFs and QEs, especially at 20eV.

Very nice talk by our colleague Janneke Weiss on the power of long-read genome sequencing - during our #PacBioDay

Our scoping review on the ethical, legal, (psycho)social and economical implications( ELSI) of reanalysis of genomic data is out! Read the full paper here: nature.com/articles/s4143…
UMCG Genetica marijevdgeest
Morris Swertz Irene van Langen Anneke Lucassen

Several New Investments in Mass Spectrometry and Proteomics Infrastructure at Utrecht University uu.nl/en/news/severa…

💡Deliverable 1.3 aims to provide FAIR cataloguing tools to map existing metadata and to support data harmonisation

The authors are Morris Swertz, Gerieke Been, Joeri van der Velde, and Ype Zijlstra, project partners at UMCG Genetica

Read the deliverable: emp.onl/JyDyN

Chemists break barriers and open up super-resolution molecule mass analysis uu.nl/en/news/chemis…

We compared the precision to being able to tell that 1 sugar grain is missing from a full bag of 1 kg of sugar. These developments are important for the quality control of advances biotherapeutics, such as vaccines and gene-delivery vehicles. nature.com/articles/s4159…

By tracing single molecules trapped into an Orbitrap cage for hundreds of km, we could determine their mass with unprecedented precision, breaking a world-record in mass resolution. The mass of a nanocage of about 500000 Da could be measured within an error of 0,5 Da. Faculty of Science, Utrecht University

Interested in lipid-associated macrophage dynamics in adipose tissue under weight loss? Check out the thread and our new release:
nature.com/articles/s4146…

What will it take to validate biomarkers of #aging and accelerate their adoption in clinical trials? In their Review, Luigi Ferrucci and colleagues discuss progress, challenges and solutions.
Prof Steve Horvath Mahdi Moqri, PhD The National Institute on Aging (NIA) Gladyshev Lab Harvard Medical School
nature.com/articles/s4159…

It's great to see our practical recommendations for implementing FAIR Principles for Research Software highlighted by ELIXIR Europe

EATRIS X-omics

Excited to be one of the early-access site for the new Stratys instrument.
Thrilled by the (long-read genomics) innovations happening at Human Genetics Nijmegen, Radboudumc Radboudumc! Kornelia Neveling Janneke Weiss Lisenka Vissers globenewswire.com/en/news-releas…

Final program for the X-omics festival 2024!
More information and full titles can be found on our website aanmelder.nl/x-omicsfestiva….

Registration is open via aanmelder.nl/x-omicsfestiva….

#xomics #multiomics #genomics #proteomics #metabolomics #dataintegration

Check out our latest paper on clonal hematopoiesis in a cohort of individuals with obesity JAHA ahajournals.org/doi/10.1161/JA… Niels Riksen Alexander Hoischen Radboudumc #clonalhematopoiesis

Great collaborative study with the labs of Adrian Isaacs rik van der kant and others showing how lipid composition describes and potentially rescues a FTD/ALS disease phenotype 👇

Neuronal polyunsaturated fatty acids are protective in FTD/ALS biorxiv.org/content/10.110…

Nicely timed for the 10th anniversary of the Lorentz Center meeting that first formulated the #FAIRprinciples , read a Q&A on a new “FAIR Digital Object” case study.

A Decade of FAIR – what happens next? Q&A on FAIR workflows with X-omics gigasciencejournal.com/blog/fa