The APL neuron is the longest cell in the fly connectome. There are only 2 in the brain. Each one is 20x longer than the fly's whole body and has well over 100,000 synapses. Explore the fantastic APL cell in Codex: codex.flywire.ai/app/cell_detai…

Next time someone bugs you, tell them to buzz off. Flies share ~70% of genes with humans, including genes for learning and circadian rhythms.

A team of researchers and citizen scientists led by Princeton University neuroscientists Murthy Lab and Sebastian Seung has created the first ever complete map of a centralized adult brain: the fruit fly 🪰🧠 princeton.edu/news/2024/10/0…

Hard to overstate how pleased I am that the #flywire consortium converted our FAFB ("Full Adult Fly Brain") EM volume into a connectome, and that the resulting science has been (and will be) so impactful. Thanks to everyone involved.

Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today

A historic milestone for neuroscience! It's been a fantastic journey for the #FlyWire Consortium. This special edition of Nature showcases the power of open science, with nine papers that not only describe the fly connectome, but also make discoveries using it.

Incredibly proud and grateful to be part of the #FlyWire team that made this happen. This was an immensely collaborative project - on every level from early open data sharing, to tool building, to analysis - over many years, across many institutions. It's been a fantastic journey

Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to Sven Dorkenwald and Philipp Schlegel, first authors of the connectome papers, Murthy Lab Sebastian Seung for establishing #flywire to make this possible and Davi Bock for birthing this dataset.

Memories. With Srini Turaga at #SfN 2007, waiting to deliver my Presidential Special Lecture, "The Once and Future Science of Neural Networks." Pinstripe suit with hot pink trim by Moschino and I really needed a haircut.

Sydney Brenner established C. elegans as a model organism starting in the 1960s, which led to the first connectome in 1986. In Sept 2007, we invited Sydney to deliver the inaugural lecture for our new Harvard University Massachusetts Institute of Technology (MIT) class on connectomics, and shockingly he accepted!

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

After today's The Nobel Prize news conference, Princeton Neuroscience Institute professor Sebastian Seung weighed in on John Hopfield's work in answering some of the universe's greatest questions.

A cell with 3 nuclei (cyan) videoed through a microscope. Mitochondria (yellow) and the actin cytoskeleton (red) are also shown. #CellBiology

Born in 1993 The Nobel Prize #VictorAmbros #RosalindLee

Finally out. advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

As people that know me well can attest, I love a good mystery! 🔍 Fortunately for me, this work had twists both surprising and peculiar. 🧵

A starburst, the first cell proofread by a citizen scientist (Krzysztof Kruk) in the alpha launch of Eyewire 2. next gen citizen science projects in the earliest stage ~ pyr.ai This amacrine cell is an interneuron that can act as a local processing unit.

the best researchers from Meta, Yale, Stanford, Google DeepMind, and Microsoft laid out all we know about Agents in a 264-page paper [book], here are some of their key findings:

An important addition to the Nature paper, beyond what was shown in the 2024 preprint, is 12 rounds of iterative imaging and sectioning of a LICONN volume, achieving 205 microns in axial extent (native scale) with manual tracing of axons: nature.com/articles/s4158…

Need an easier way to visualize and collaborate on large-scale volumetric images? Join our live Q&A 'Extending the Neuroglancer Paradigm: Advancing Collaboration on Large-Scale Imaging Data' 👉 Register here: events.zoom.us/e/view/UtTwLDv… 🗓 Tuesday, July 29th | 12:30pm - 2:00pm ET