Jack Silberstein
@jack_silb
Antibody Discovery and Protein Engineering at Stealth NewCo | Novel Immunotherapies for Cancer & Autoimmunity | @StanfordImmuno PhD & @StanfordBioX Fellow
ID: 1243977220516753408
28-03-2020 19:04:23
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That aged like a fine wine Pfizer Inc. #sold
Happy to share our lab's first manuscript. In work led by Johanna Theruvath, we tested a combo of FDA approved anti-GD2 with blockade of CD47, a macrophage checkpoint. Blocking CD47 unleashes patients' macrophages to phagocytose or 'eat' cancer cells. Combo was highly effective! 1/
Congratulations Carolyn Bertozzi!!
Nice piece on exciting new work from CochranLab Stanford Engineering, structure of immune therapy target LAG-3 bound to agonist antibody showing importance of disrupting dimer interface, just published PNASNews news.stanford.edu/2024/03/11/pro…
I am excited to share our Nature Communications paper describing the structure of #LAG3 bound to MHC-II. This project was carried out by Q&M et al at Moffitt Research and provides new insights into the mechanism by which LAG3 suppresses T cell activation. nature.com/articles/s4146…