New Gastroenterology study by Suresh Chari MD Anderson Cancer Center: The 1st prospective study to estimate the risk of #PancreaticCancer in individuals with new onset diabetes based on glycemic criteria (G-NOD) shows profound impact of race/ethnicity, with Whites having highest risk (SIR 6.4)

Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with OmicVision Andreas Mund Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!

A special Journal of Clinical Investigation series on #PancreaticCancer led by Ben Stanger jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… Articles by Laura DeLong Wood Muir Lab Maddipati Lab

🚨 A warning from NIH Do not use “substantial” #AI generated content in your grants! “the detection of AI is identified post award, NIH may refer the matter to the Office of Research Integrity….” NIH is also limiting grant submissions to SIX per year. grants.nih.gov/grants/guide/n…

Fascinating & important Cell paper from Helmholtz Munich | @HelmholtzMunich Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia cell.com/cell/fulltext/… A study that links deregulation of the hepatic circadian clock with peripheral tissue wasting.

NCI Interim Funding Policy: “With these considerations, we expect to fund through the 4th percentile for those established investigator applications.” “It is expected that funds will be available to reach the 10th percentile for those Early Stage Investigator applications.” 😢

New iScience journal paper by Dr. Nina Steele PascaLab Primary and metastatic cellular landscapes in human #PancreaticCancer cell.com/iscience/fullt… Signatures of pancreatic cancer metastases associated T cells (exhausted), macrophages (complement pathway) and fibroblasts (UPP1 +).

Wish you all the best, Anirban! Thank you so much for your kind support and guidance on my early independent research career 🙂

Online Now: When human cancer goes neural dlvr.it/TM6kKV

I asked our in house expert Andrea Viale and he recommends the following product if you are worried about microplastics in your chewing gum: simplygum.com/collections/gum Some other thoughts on environmental microplastics exposure & health from Andrea: mdanderson.org/cancerwise/und…

An #OpenAccess review in Cancer Cell on circulating tumor cells (CTCs) from the prolific Mass General Cancer Center group: Circulating tumor cells: Blood-based detection, molecular biology, and clinical applications cell.com/cancer-cell/fu…

Studies have shown that the NSD2 protein fuels cancer growth, particularly in difficult-to-treat cancers with KRAS mutations. A new multi-institutional study confirmed that NSD2 can be targeted with a new drug. Learn more: spr.ly/6015fcGXS #EndCancer

In the Spotlight: Two Shots on Goal: Combination of RAS Inhibition and Immunotherapy Drives Long-term Remission in Pancreatic Cancer - by Emily Lasse Opsahl and Marina Pasca di Magliano pasquale calabrese at U-M Rogel Cancer Center brnw.ch/21wURxa

The final schedule of the MD Anderson Cancer Center #PancreaticCancer research symposium on Aug 19th (Tuesday) is below. What an impressive line up of experts covering the entire gamut of expertise in pancreatic cancer from cancer biology to cancer biomarkers to cancer therapeutics! 🫡

Fantastic lecture by David S. Hong MD on targeting KRAS in #PancreaticCancer. MD Anderson Cancer Center has the largest portfolio of KRAS inhibitor trials (👀 slide 1!), his favorite G12C “children”, how KRAS inhibitors are stacking up against chemotherapy, and of course Roger Bannister!

A terrific send-off for Anirban Maitra at today’s pancreatic cancer symposium. A Texas-sized thank you to everyone who participated! We showcased the first-class science and clinical care at MD Anderson Cancer Center, discovered hidden artistic talents, and perhaps a new profile pic…

Bittersweet day: said farewell to Anirban Maitra as he departs MD Anderson Cancer Center for NYU (wonderful speech/symposium), & me announced as Scientific Director of the Ahmed Center for Pancreatic Cancer Research (!!). Anirban Maitra–thanks for an amazing 12 yrs and prepping me for this role 🙏

Amazing nature paper by moran amit & the MD Anderson Cancer Center cancer neuroscience team. Cancer is a wound that does not heal but now we learn that injury phenomenon also extends to nerves! Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy nature.com/articles/s4158…

Terrific preprint by Hartland Jackson using imaging mass cytometry (IMC) & matched genomics for building multimodality prediction models: Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations biorxiv.org/content/10.110…

New Cell Reports paper by Andrew Aguirre Hale Family Center For Pancreatic Cancer Research Integrative genomic identification of therapeutic targets for #PancreaticCancer cell.com/cell-reports/f… VERY GOOD use of public datasets (DepMap, CCLE, TCGA, GTEx) to identify cell intrinsic & cell surface dependencies