Hugely thankful to ICIS 🦋 @cytokinesociety.bsky.social and to EFIS for giving me the opportunity to present my PhD project on the interaction between microbiome and endometrial epithelium at #cytokines2023!

Delighted to share our latest piece all about how the Krebs cycle enzyme Fumarate hydratase regulates immunity from Luke O'Neill, Shane O'Carroll, and myself out now in Trends Cell Biology authors.elsevier.com/a/1i2VJ_LvCM5J…

Excited to share our article is live on the Journal of Immunology! We explore an itaconate derivative's impact on eosinophil development & airway inflammation. Huge thanks to the incredibleteam and my PhD supervisor Luke O'Neill! TCD TBSI 📚 #Research #Immunology

The Luke O’Neill Lab are in BSI Congress & Events Come see our posters regarding all things Itaconate & derivatives from Emily Day (P-258), Maureen Yin, PhD (P-133), Yukun Min 闵煜昆 (257) and myself (P-259)! Christian Peace will present his work on Wednesday at 11:45 in Hall2A! #BSI23

I’m at BSI Congress & Events! Join me at Poster 259 to chat all things itaconate and type-I interferon #BSI23

Nature review article: A break in mitochondrial endosymbiosis as a basis for inflammatory diseases go.nature.com/3OAPC0C

Our review on mitochondria and inflammatory diseases is out now. Is a break in the 2 billion year old endosymbiotic relationship with mitochondria a basis for RA, MS, IBD, asthma and more? rdcu.be/dx4Vv pubmed.ncbi.nlm.nih.gov/38326590/

Our latest review from Luke O'Neill, Fiona Henkel, and myself is all about the "Metabolic regulation of type-I interferon production" and is available now in Immunological Reviews! onlinelibrary.wiley.com/doi/epdf/10.11… #Immunometabolism #Interferon

RESEARCH |Shuke Xiao 肖舒克, Long Lab et al. (Stanford Pathology): #Metformin triggers production & release of Lac-Phe from the gut, which is required for its effects on food intake & weight loss. ⚕️💊 nature.com/articles/s4225…

Unlocking potential: the role of the electron transport chain in immunometabolism. Check out this feature review by TCD TBSI Luke O'Neill, Alessia Zotta & Maureen Yin, PhD in Trends in Immunology #AAI2024 hubs.ly/Q02vSsxY0

Online now! A systematic mutational framework for studying oxidative phosphorylation-related proteins dlvr.it/T6dHHl

New! Online now: Gut microbial alterations in arginine metabolism determine bone mechanical adaptation dlvr.it/T71YdX

Excited to announce the first review from the lab is now available online. If you love #mitochondria take a look at our exploration of this topic in innate immunity. MRC MBU MRC MBU Postdocs Eloïse Marques 'Multifaceted mitochondria in innate immunity' nature.com/articles/s4432…

Very excited to share that in a few short weeks I will be starting as an Assistant Professor at Western University in Physiology and Pharmacology Phys Pharm! If you are interested in immunometabolism and metabolic disease please reach out! Hiring at multiple positions!

I am grateful for all the opportunities and mentors I had at Trinity College Dublin Trinity College Dublin and will miss my friends and colleagues from TBSI TCD TBSI very much - it has been a great place to work and learn over the past 3.5 years!

Welcome to our newest faculty member Dr. Emily Day Emily Day!! Emily joins us from Trinity College in Dublin and is working on the intersection of inflammation and metabolism. Happy to have you Emily!!!

Delighted to share new work from my PhD along with Christian Peace and Luke O'Neill on how itaconate regulates IFNs in Nature Metabolism. Check out the Tweetorial below!

#ImmunometabolismPower! Christian Peace Shane O'Carroll Luke O'Neill &co show Nature Metabolism that itaconate drives type I #interferons by inhibiting SDH & driving #mitochondrial RNA release via VDAC1, thus activating RIG-I/MDA5! nature.com/articles/s4225…

Lovely work and congrats all!

Scientists from TCD TBSI, led by Prof. Luke O'Neill, have discovered a new process in our immune systems that leads to the production of key anti-virals. They hope the work will lead to new therapies for #autoimmune and #infectious diseases. Read more at: tcd.ie/news_events/ar…