Today we report in Nature Medicine the development of a base editing strategy for prion disease, currently a fatal and rapidly progressing neurogenerative condition with no effective treatment. @PrionAlliance DevermanLab (1/13) drive.google.com/file/d/1DVpKrz…

That’s my Canada. Peaceful, trustworthy, supportive, world-class excellence. I stand on guard for thee.

New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). IBEC

Two absolutely fantastic bioimage analysis papers out today offering exceptional, generalizable tools for segmentation--Cellpose3 and Segment Anything for Microscopy. (1/3)

Five years of work, one big question: Which has a greater impact on aging—our environment or our genes? I'm excited to share our paper published today in Nature Medicine, demonstrating the major role of the #exposome in shaping mortality and #aging. nature.com/articles/s4159…

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in Nature Methods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

No words.

Our live imaging video of muscle cell fusion is hosted on HHMI's Beautiful Biology! Thanks BB for selecting our video and congratulations to Yue Lu! hhmi.org/beautifulbiolo…

Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 Nature Medicine

Ready for the most powerful foundation model for medical images/videos? 🚨 Just dropped: MedSAM2 The next-gen foundation model for 3D medical image & video segmentation — built on top of SAM 2.1. • Project site: medsam2.github.io • Paper: arxiv.org/abs/2504.03600 Why

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…

63 biliary cancer cell lines!! An unbelievable resource from the Bardeesy Lab Mass General Cancer Center

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15

The brain is the master regulator of food intake and energy balance. A brilliant new Cell review, including the mechanism of GLP-1 drugs, by Christoffer Clemmensen and colleagues, open-access cell.com/cell/fulltext/…

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out!

When the PI hasn't worked in at the bench in years but needs to do something in the lab for a photoshoot

Excited to share that my PhD thesis work is out in Science Magazine today. We demonstrate robust rearrangement of the human genome using bridge recombinases, performing programmable insertions, excisions, and inversions at megabase-scale.

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing 🔵 Lifeact & 🔴 RFP-nls Honored & grateful to receive an honorable mention at Nikon Microscope Solutions Nikon Small World 🌍🔬✨ 🔗 nikonsmallworld.com/galleries/2025… #NikonSmallWorld #Microscopy #ScienceArt

an absolute shame. @harvard cutting PhD admissions "The Organismic and Evolutionary Biology department will shrink its class size by roughly 75 percent to three new Ph.D. students [...] Molecular and Cellular Biology will reduce its figure to four new students, and Chemistry and