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Type I interferons induced upon respiratory viral infection impair lung metastatic initiation biorxiv.org/cgi/content/sh… #biorxiv_immuno

#ImmunometabolismPower! Rao, Feng &co show Immunity that the pyrimidine synthesis enzyme CTPS1 also deamidates IRF3, blocking type I #interferon induction. Virus sensing activates GSK3b inhibiting CTPS1 & allowing #IFN production! Doi.org/10.1016/j.immu…

So excited to have this paper out now! Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. cell.com/cell/abstract/… @uconnresearch UConn Health 1/3

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus rdcu.be/d5CtA

🚨 Stop chasing the p-value! Increasing your sample size will always yield a significant result. Even for trivial differences. 🎮 I created a little interactive playground to illustrate this issue: react-graph-gallery.com/example/t-test… Always pair p-values with effect sizes!

Happy to share our new publication exploring how Interferon-gamma rescues dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching Darius Armstrong-James Nonni 💙 Imperial Department of Infectious Disease #Aspergillus 🍄 #Immunotherapy cell.com/iscience/fullt…

More evidence accumulates that pyroptosis is regulated by ROS after GSDMD cleavage occurs. A beautiful mechanistic study on mitochondrial ROS acting downstream of NLRP3 activation. Kudos to all authors. nature.com/articles/s4225…

During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival Science Immunology Kathleen Mills, PhD Tobias Hohl is now @fungalspore.bsky.social science.org/doi/10.1126/sc…

Characterizing extracellular vesicles of human fungal pathogens - new PERSPECTIVE by Rodrigues & colleagues out now Neil Gow David Andes Arturo Casadevall Josh Nosanchuk Guilhem Janbon Marcio L. Rodrigues Leonardo Nimrichter Read it here: rdcu.be/efmxx nature.com/articles/s4156…

Fun project that started with looking at whether or not there is chaos during Galleria infections, and wound up also finding some interesting patterns that occur of infection (and lots of mesmerizing timelapses) Arturo Casadevall biorxiv.org/content/10.110…

So excited to announce that I successfully defended my dissertation last week! I am incredibly thankful for everyone that helped me along the way during my time in the ObarLab. 🍄🐁🫁 Dartmouth MCB Graduate Program Dartmouth 🌲

A new review from Dr. Kristin Hogquist at UMN Laboratory Medicine and Pathology focuses on interferon (IFN) production within the thymus and its effects on thymic APCs and developing thymocyte while also examining the importance of T-cell tolerance to IFN. Read it in The JI: ow.ly/XmE450VEIxE

Our recent study out today in PLOS Pathogens Identified Candida auris induces IFNgamma to colonize the skin. journals.plos.org/plospathogens/…

🫁 Updated preprint for our first manuscript with Andrew Olive looking at why alveolar macrophages drive strong type I IFN responses after TLR2 activation; we uncovered a surprising role for and mitochondria ROS and MAVS signaling - find out more here: biorxiv.org/content/10.110…

New online! A gut fungus protects the liver nature.com/articles/s4157…

Glad to have the first story during my postdoc in Eric’s lab. We investigated the fungal latent infection contained by type 2 granulomas in mouse models. Hope you find it interesting.

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production Science Immunology Poltorak Lab science.org/doi/10.1126/sc…

#WeekendRead! #NoTimeToDie! Welcome to a new form of cell death: #efferoptosis! Poltorak, Muendlein &co show Science Immunology that during systemic inflammation TNF reprograms efferocytic macrophages to activate caspase-8 (not NLRP3!) pyrotosis & IL1b release science.org/doi/10.1126/sc…

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement Cell Thomas Carell Veit Hornung Marleen Bérouti cell.com/cell/fulltext/…

#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show Molecular Cell that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! cell.com/molecular-cell…