1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…

Merry Christmas!

Buon Anno!

The outer ear is a mammalian innovation but where did it come from? In our study in nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. nature.com/articles/s4158… 1/n

*Every single* cure for a disease ultimately flowed from basic exploratory research. Stopping basic research is like stopping the mountain rains and expecting rivers of cures to still flow. Examples: 1) studying saliva of Gila monster -> GLP1's 2) studying funghi -> first

after ten years of research, they are here scientists created mice with human-like telomeres that experience real cellular aging. this might be the biggest breakthrough in longevity science in decades 1/

Trump's lawyers are absolutely flailing in the courts right now

#mRNAvaccines for #PancreaticCancer (PDAC) PART4 1. Out today in nature nature.com/articles/s4158… 🧵👇🏽 [1/23]

"More than 99% of new drug approvals (2010-2019) were funded by NIH. Why dismantle the engine that made the U.S. a world leader in innovation and drug development ? #DoNotDefundScience jamanetwork.com/journals/jama-…

1/Metastasis can stay dormant for years before reactivating and becoming lethal. But what wakes them up? A new study uncovers a fascinating mechanism involving epigenetics and immune suppression. Let’s break it down! 🧵 #metastasis #cancer #oncology #science #Immunology #dormancy

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

Fine, here we go. First let's start with some baseline expectations. Pancreatic cancer is scary, 5y survival is ~10%. So if you see a trial with an apparent survival asymptote at ~50% then certainly *something* is happening, right?

In 1993 Ukraine *gave up their nukes* in exchange for a guarantee of future protection from the USA. If the USA isn't going to keep their word (which is a scummy beta move) then give them back the same amount of nukes that were destroyed so they can protect their own selves.

It would’ve been a show of strength for the President of the United States to bring the elected leader of Ukraine to the Oval Office and engage with him in a dignified way.   But you would never know that after President Trump’s shameful display. Putin must be overjoyed with

Too many people take biomedical innovation for granted.

We are walking the Ullswater Way with OSCAR's PBTC in May. Learn more and donate here: justgiving.com/team/thalia #braintumours #childhoodcancer #cancer

I am excited to present our new study out in Nature Medicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the Tony Wyss-Coray lab. 🧵1/12 Full study 🔗: nature.com/articles/s4159…

Prevention beats cure, which is why it's so exciting that Lenacapavir, a twice-yearly HIV preventative, just got approved for the first time (by the FDA) Why is it such a big deal? When trialled (in women in South Africa and Uganda) there were 0 HIV infections 🧵

'Night science' is what you do when you're not sure what's the question.

Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!