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ASO technology using exogenous delivery of antisense oligonucleotides offers many diverse applications, from killing pathogens to reprogramming genetically intractable microbes. Time to organize the first conference on ASOs & microbes! Register at helmholtz-hiri.de

We are organising a mini conference on the diverse applications of Antisense oligonucleotides to manipulate bacteria. Apart from a stellar line-up, Würzburg itself offers a beautiful setting. Spread the word and join us.

Excited to share our preprint Jörg Vogel 𝗡𝗼𝗻-𝗴𝗲𝗻𝗲𝘁𝗶𝗰 𝗺𝗲𝘀𝘀𝗲𝗻𝗴𝗲𝗿 𝗥𝗡𝗔 𝘀𝗶𝗹𝗲𝗻𝗰𝗶𝗻𝗴 𝗿𝗲𝘃𝗲𝗮𝗹𝘀 𝗲𝘀𝘀𝗲𝗻𝘁𝗶𝗮𝗹 𝗴𝗲𝗻𝗲𝘀 𝗶𝗻 𝗽𝗵𝗮𝗴𝗲-𝗵𝗼𝘀𝘁 𝗶𝗻𝘁𝗲𝗿𝗽𝗹𝗮𝘆 doi.org/10.1101/2024.0… Universität Würzburg #UniWürzburg Helmholtz Institute Würzburg (HIRI) New Concepts in Prokaryotic Virus-Host Interaction #biotech #microbio #phage

Shall we start calling them „asobiotics“? Probably easier than „antisense-based antibiotics“ or „antibacterial peptide-delivered antisense drugs“, to name just a few of the current names. To be discussed. Anyway, ASOBIOTICS 2024 was a big success. Big thanks to everyone involved.

New review article in The Lancet Microbe Antimicrobial resistance: a concise update thelancet.com/journals/lanmi… #AMR #OpenAccess #OA

Antimicrobial resistance could kill 40M by 2050. It is one of the greatest challenges of our time. Check out our latest article in The Lancet Microbe The Lancet to learn about its impact and how AI and other innovations can help fight it. 🦠🤖 thelancet.com/journals/lanmi…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

Excellent analysis of why new antibiotics don’t make it to patients. Plazomicin (Achaogen) financial post-mortem ⁦John H. Rex, MD⁩ amr.solutions/2024/10/14/pla…

I am excited to finally share this preprint from Jörg Vogel. We've developed a reporter assay to enable high throughput discovery of carriers for ASOs into bacteria. This was a challenging and exciting journey for me, from MedChem/ChemBio into Mol/SynBio.

Very happy to share the recently published collection on "Biologically Active Natural Products" together with Journal of Natural Products, ACS Pharmacology & Translational Science, and ACS Infectious Diseases! Link: pubs.acs.org/page/vi/biolog… ACS Publications ACS Publications Bio & Med Chem Content Sonja Krane

Today's Lancet climate and health report presents 56 indicators of health and climate change across FIVE domains. (Download the report for free from the Lancet website). Here is a thread of some of the key findings. #Lancetclimate24 (1)

Proton motive force and antibiotic tolerance in bacteria "maintaining proton motive force is necessary for the survival of antibiotic persisters" …icro-journals.onlinelibrary.wiley.com/doi/10.1111/17…

Exciting news! I started the junior research group 'Complexes in Phage-infected Cells' at Helmholtz Centre for Infection research Helmholtz-Zentrum für Infektionsforschung –inaktiv looking forward to explore new jumbo phage biology. We’re hiring! Join us for a PhD position.

Have a look at this CFP Editorial, on the upcoming Special Issue at ACS ID- "Microbiota, Infections, and Host Immunity"! Inviting submissions on microbiome research in infectious diseases! ACS Publications ACS Publications Bio & Med Chem Content Yuan shorturl.at/3kxw0

Over the moon to be named among the #50ScientistsThatInspire across diverse fields by Cell! A heartfelt thank you to my former and current lab members, mentors, collaborators, and friends—you are my daily inspiration! cell.com/news-do/50-ins…

Bactericidal antibiotics release DNA that activates TLR9, while static antibiotics do not. Can profoundly impact treatment outcome. Should clinicians consider this when choosing antibiotics? Amazing work by Julia Gross and collaboration with Iain Fraser! nature.com/articles/s4146…

These are the 20 most-studied bacteria — the majority have been ignored go.nature.com/3C6pFTR

The fungal crisis is here and desperately needs addressing: A quick assessment of the armamentarium of antifungal agents shows just how underprepared countries are...fungal infections receive less than 1.5% of all infectious disease research funding statnews.com/2023/02/09/fun… #AMR

It was a pleasure to host Cèsar de la Fuentez César de la Fuente in Würzburg! A great day spent learning more about his excellent work on applying AI to antibiotic discovery and exchanging thoughts on other things. Looking forward to our paths crossing again.