Wu et al. describe the clinical and radiological features of genetic leukoencephalopathies in a large cohort of 309 adults, and find that the most frequently mutated genes are NOTCH3 (25%), NOTCH2NLC (19%), ABCD1 (9%), CSF1R (7%) and HTRA1 (5%). tinyurl.com/y28fhfyp

Fantastic day Research at ARUK UCL Brain Sciences speaking to interested members of the public about our UK Dementia Research Institute work at the Care Research and Technology Centre Imperial Department of Brain Sciences using and designing technology with, and for, people living with dementia, well done team 🎖️

Terrific news today as results from phase 3 trial of #Alzheimers drug donanemab presented at #AAIC23 confirm the drug significantly reduced amyloid in the brain & slowed disease progression👏 🧠 UK DRI researchers comment on the encouraging results🙌 👉buff.ly/3K0pr1c

Fantastic to hear from our incoming Director, Prof Siddharthan Chandran, at the Dementia Mission event at #AAIC23 yesterday! Prof Chandran discussed the important role the UK DRI can play in the Mission - both in discovery research and translation👏

Interesting study need more like this please looking at dementia risk factors. Frustratingly ambiguous findings (primary outcome solidly negative) further targeted trial work needed for hearing aids, but some suggestive benefits in high risk subgroups. More biomarkers/ diagnoses?

Congratulations ⁦Jonathan Schott⁩! Great leadership in the Alzheimer’s field.

Dr Giovanna Lalli, the UK DRI's Director of Scientific Affairs, is British Neuroscience Association's Face of the Fortnight!🙌 Stay tuned to BNA's feed to hear from Giovanna over the next couple of weeks. Find out more👉buff.ly/3K6Rz2H

By analysing videos of concussions in professional American football games and modelling the impacts, Zimmerman et al. show that loss of consciousness is associated with deformation in brainstem regions containing nuclei involved in arousal. tinyurl.com/2s4kp6x6

Thanks Adel.

So much respect for England Cricket and Cricket Australia for raising awareness of dementia in such a powerful way (and for entertaining us with such wonderful cricket all through this Ashes series)

Acetylcholine modulates the temporal dynamics of human theta oscillations during memory nature.com/articles/s4146… #neuroscience

This month's Brain contains a set of important articles on #Parkinsons and #LewyBody dementia, including reviews on alpha-synuclein and bradykinesia, papers on cholinergic loss, mechanisms underlying rigidity, impulse control disorder and cognition academic.oup.com/brain/issue

Congratulations!

Pleased to see this comment with @Neurosharp published looking at the great work of the TRACK TBI team on dynamic patient trajectories years post-injury. More to be done to understand things at a mechanistic level but key implications for patient monitoring & treatment trials.

No big deal - solanezumab targeted soluble monomers the idea being to pull amyloid out of the brain like a sponge - but it didn’t clear amyloid. I really don’t understand why the company pursued it so long I would have dropped years ago (easy to say now)

Super interesting review from Sarah Marzi on the application of AI and machine learning in experimental medicine for dementia research👩‍💻👩‍🔬🧠 Read more in Alzheimer's & Dementia Journals👉buff.ly/3PzcVb8

Fantastic to speak at this years UK Dementia Research Institute Connectome event about…well….me. Really enjoyed speaking about my path, the wheel of skills and working in the grey (where the magic happens). Finding out about my panel members was an amazing bonus!

Really interesting! Although traumatic brain injury (TBI) is associated with ⬆️ Alzheimer's risk and ⬆️ phospho-tau181, this study shows phospho-tau181 is not elevated in the first year after moderate-to-severe TBI jnnp.bmj.com/content/early/… Neil Graham, Jonathan Schott, @Neurosharp

Can’t believe it’s been a week since our launch of Friend’s of the Care Research & Technology Centre (Friend’s of CR&T), fantastic event bringing together those interested in being at the heart of our research, find out more 👉 imperial.ac.uk/uk-dri-care-re…

Many congratulations to Inga Koerte and Nikolaus Plesnila for an excellent European Neurotrauma Organisation (ENO) meeting. Great fun, great hospitality and great scientific programme.