From JAMA Cardiology: In this pooled analysis of PARADIGM-HF/PARAGON-HF RCTs, sacubitril/valsartan significantly reduced all-cause hospitalization in heart failure, particularly in pts with LVEF <60%, driven by decreased cardiopulmonary events. ja.ma/4e5zuhZ #ESCCongress

Pooled analysis of patients with HFpEF in STEP-HFpEF, SELECT, and FLOW Mikhail Kosiborod Saint Luke's Mid America Heart Institute Saint Luke's Muthu Vaduganathan

A review of 3 trials in persons with type 2 diabetes, demonstrated consistent cardiovascular and kidney benefits of GLP-1 receptor agonists regardless of SGLT2 inhibitor use Circulation ahajournals.org/doi/10.1161/CI… #T2D #heartdisease #heartfailure #CKD

Presented at #ESCardio: Among patients with transthyretin amyloidosis with cardiomyopathy, the risk of death from any cause and recurrent cardiovascular events was lower with vutrisiran treatment than with placebo. Full HELIOS-B trial results: nej.md/3X5nl5Q

Effects of Sacubitril/Valsartan on All-Cause Hospitalizations in Heart Failure Post Hoc Analysis of the #PARADIGM-HF and #PARAGON-HF 👥13 194 ⏰ 2.5 (1.8-3.1) years 👉Sacubitril/valsartan significantly ⬇️ 8% risk of all-cause 🏥 (ACH) 🆚 RASi 👉NNT of 48 patient-years of

Implementing Medical Therapy During Worsening #HeartFailure released at #ESCCongress and just published in #EHJ👉 bit.ly/4cMFoUg EHJ Editor-in-Chief Ankeet S. Bhatt, MD, MBA

“The risks of omission in #heartfailure management - speeding up the implementation of guideline-directed heart failure therapy” Stellar panel of experts - Carys Barton 💙🫀#25in25 #Freedomfromfailure Muthu Vaduganathan Steve Greene Gianluigi Savarese

New analysis from CANVAS and CREDENCE trials reveals a bidirectional relationship between CV events and #CKD progression in type 2 #diabetes bit.ly/3X747wK #ESCCongress #JACC #T2D #MACE Brendon Neuen Muthu Vaduganathan

Bidirectional Relationship Between Kidney Disease Progression and Cardiovascular Events in #T2DM jacc.org/doi/full/10.10… Brendon Neuen Muthu Vaduganathan JACC Journals #ESCCongress European Society of Cardiology

Implementing Medical Therapy During Worsening Heart Failure Ankeet S. Bhatt, MD, MBA Muthu Vaduganathan academic.oup.com/eurheartj/adva… #WHF #HeartFailure #ESCCongress European Society of Cardiology Journals European Society of Cardiology EJHF Editor-in-Chief

Beta-blocker use and outcomes in patients with #HeartFailure and mildly reduced and preserved ejection fraction released at #ESCCongress and just published in #EJHF👉 bit.ly/3Tbt2hr EJHF Editor-in-Chief Faiez ZANNAD

Loss of kidney function accelerates dramatically after HF, while atherosclerotic & HF risk increases 3-4 fold after CKD progression Highlighting epidemiological & therapeutic synergies between CKD & CV disease Cardio-kidney-metabolic #simpub for #ESCCongress in JACC Journals

Pooled data from ~15,000 pts in 4-RCTs examining the relationship b/w NT-proBNP, kidney function & outcomes in HFpEF Data which calls into question proposals for higher NT-proBNP references ranges in people with CKD #Simpub in JACC-HF for #ESCCongress sciencedirect.com/science/articl…

🔥 A new therapeutic era in #HFpEF #FINEARTSHF with definitive evidence supporting the role of the non-steroidal MRA finerenone at #ESCCongress Now in NEJM nejm.org/doi/full/10.10…

What an incredible #ESCCongress - so much fantastic and practice changing science Our The George Institute for Global Health/Brigham and Women's Hospital Harvard Medical School publications on the intersection of heart failure & CKD featured in Nature Medicine, Circulation, JACC Journals, and The Lancet Public Health

An analysis of three phase 3 trials testing finerenone in patients with heart failure and chronic kidney disease with type 2 diabetes provides an integrated view of the mortality, cardiovascular and renal effects of this treatment nature.com/articles/s4159…

In the second season of a pragmatic trial involving all Danish individuals above 65 years of age, electronic nudges increased influenza vaccination rates significantly with respect to usual care, with higher effect in individuals not previously vaccinated nature.com/articles/s4159…

#Sacubitril/valsartan reduces incident #anaemia and iron therapy utilization in heart failure: The #PARAGON-HF trial European Society of Cardiology Journals Muthu Vaduganathan Carolyn Lam Pardeep S Jhund scottdavidsolomon Full 📝 👇🏻 onlinelibrary.wiley.com/doi/full/10.10… Henry Han Amr Abdin Giuseppe Galati Marco Metra

Incredibly happy to see the primary results of our 2nd NUDGE trial published in Nature Medicine! In summary, we found that electronic nudges remained effective in increasing flu vacc rates when administered over consecutive seasons 💉 ⬆️ Tor Biering-Sørensen, MD, MSc, MPH, PhD Muthu Vaduganathan Ankeet S. Bhatt, MD, MBA