Proud moment! Our clinic is from now on Hypertension Excellence Center, according to European Society of Hypertension

Adrian Covic Vlad Cristiana MD Ionuț Nistor Luminita Voroneanu Mugurel Apetrii

Happy to share my *first ever* Visual Abstract!!
All thanks to my amazing mentors at Nephrology Education Collective Internship!

Reference article: journals.lww.com/jasn/fulltext/…

Jade Teakell Evan Zeitler I didn't let that dissuade me 😎....fortunately

it lead to this medium.com/@hswapnil/a-tw…

and the first ever #NephJC a week later nephjc.com/ckdscreening

To be part of such an inspiring group and listen to their stories of how #nephjc started, makes all my 4 AMs (aka nightlife) in the last 2 years worth it

It is about all of us and you pitching in to create and maintain this wonderful community and keep it vibing 💗

💥Pre eclampsia: one of the important cause of PrAKI and maternal Mortality.
💠Incidence range 2-10% of Pregnancies worldwide
⚡️Let's revise with my New Infographics 👇👇👇
#pregnancy and kidney disorders

ISN Education
Women In Nephrology
The Kenyan Gyne (#HealthServiceCommission)
OBSTETRICS & GYNECOLOGY CONNECT

One of the highlights on my on call is a sodium of 107- alive and oriented, and the rear occasions I use hypertonic NaCl🧂
🔝 Almost made it to my top lowest sodiums

💗CKD and atrial fibrillation
💊DOACS seem a better option than VKAs, however, 2 trials comparing them failed to recruit the necessary number of pts

DOACs are still off-label at eGFR<30 in 🇪🇺

❤️‍🩹How about left atrial appendage closure? pubmed.ncbi.nlm.nih.gov/38656567/

DASH trial- post hoc analysis
⬇️sodium diet
📍Minimal impact on glom hemodynamics
📍Associated with lower SBP
🧂Significant reduction in eGFR vs high-sodium DASH diet
🍌Effect on eGFR decline partly mediated by changes in DBP and potassium load

journals.lww.com/kidney360/full…

⭐️Discussion⭐️
T3a: ApoE is a protein involved in the metabolism of fats.
It has been implicated in:
🧠 Alzheimer’s disease
🫀 CVD
👁️ Macular degeneration

In the 🫘 has been detected in fibrillary, immunotactoid GN, monoclonal Ig deposition disease (and, now in DDD!)
#NephJC

T0f: C3G is mainly caused by dysregulation in the complement cascade, this can be from genetic 🧬 and/or acquired 🧪 factors.
More than 90% of C3G cases are caused by dysregulation in the alternative complement cascade, while 10% are in the classical/lectin pathways. #NephJC

Sayali Thakare Nephrology Journal Club Anvitha Rangan This is one of my slides from a C3G talk. The lipodystrophy occurs due to nephritic factors leading to uncontrolled complement activation breaking down fat cells.
Unlike most other complement proteins which are made in the liver, >90% Factor D is made in adipose tissue.

Mark your calendars 🗓️, don’t miss our upcoming #NephJC chats‼️

👉 May 7 and 8: KDIGO CKD Guidelines (Stevens et al, Kidney Int 2024) Part 1
👉 May 21 and 22: KDIGO CKD Guidelines (Stevens et al, Kidney Int 2024) Part 2

T0g: Genetic 🧬 factors
♦️Most common mutations  ➡️ C3 convertase & Factor H gene

Acquired 🧪 factors
♦️Most common autoantibodies  ➡️ C3 & C5 nephritic factor

♦️Other etiologies: monoclonal gammopathy in older adults
#NephJC

📸⬇️ Sanjeev Sethi fernando fervenza NEJM. 2012.

T0h: EM 🔬 is required to distinguish between C3GN & DDD.

DDD  ➡️ extremely electron dense “sausage-shaped” deposits 🌭.  These are typically present along the glomerular, tubular basement membranes, Bowman’s capsule & mesangium.
C3GN  ➡️ not-dense/ amorphous deposits.

#NephJC

T0c: C3G is subclassified in: C3GN and DDD.

Both share many overlapping features making it a diagnostic challenge.

Check out this nice overview❗️ #NephJC
🖼️ by Anvitha Rangan

This Annals of Int Med article including over 800K hospitalists saying in case of female doctors, no matter the gender of pts👉 ⬇️30-d mortality and readmission rate
Ofc, database studies have limitations

🙏Grateful if someone could help with full version of it acpjournals.org/doi/abs/10.732…

Dense Deposit Disease not so dense anymore?

nephjc.com/news/apoe-in-c…

Join us this week on #NephJC to discuss

Super fun as always to join Freely Filtered: A NephJC Podcast - discussing all things FSGS, GFR slope / endpoint definitions, & lessons for next gen rare disease trials

Thanks Joel M. Topf, MD FACP Swapnil Hiremath @[email protected] Priya Yenebere Nayan Arora,MD Michelle Rheault for another fun episode

podcasts.apple.com/au/podcast/fre…

#nephjc

New in this episode of Freely Filtered: A NephJC Podcast, chapters!

nephjc.com/freelyfiltered…