New study Nature Medicine shows why we gain weight with age: We remove less fat as we age so if we don't eat less as we age, we gain weight btw, nuclear bombs made this study possible as they doubled atmospheric carbon-14 and as a result in our tissues nature.com/articles/s4159…

This new study in @nejm is amazing. Children with familial hypercholesterolemia treated with statins for 20 years just don't have cardiovascular events during young adulthood (unlike their affected parents). nejm.org/doi/full/10.10…

In a registry-based cohort of the full Norwegian population, genetically-confirmed familial hypercholesterolemia is associated with ~8-fold risk of incident aortic stenosis jamanetwork.com/journals/jamac… JAMA Cardiology @TheFHFoundation

Erin D. Michos, M.D. John William McEvoy Roger Blumenthal Johns Hopkins Medicine NUI NEJM And a 20-year study to show how vital it is to make the diagnosis and treat familial hypercholesterolemia early in life nejm.org/doi/full/10.10… NEJM

Holy moly: Search-and-replace genome editing without double-strand breaks or donor DNA from ⁦Broad Institute⁩ David Liu & colleagues. Theoretically able to correct ~90% of human pathogenic variants: nature.com/articles/s4158…

Thrilled to have Mike Mendelson, Boston Children's #Pediatric Preventive Cardiologist and U of M Rady Faculty alumni, here at #CHRD2019 talking about #epigenetics and how they contribute to the intergenerational inheritance of #cardiometabolic disease in humans.

So many thoughts about the ethical, social & legal implications of epigenetic aging/commerical testing after Mike Mendelson’s talk at #CHRD2019 CHRIM

A Sniderman et al masterpiece - Mass of cholesterol that will be deposited in artery is determined by the # of apoB particles that are trapped within intima. # of apoB particles that enter is determined primarily by the # of circulating apoB particles ow.ly/GtSO50wSzuD

What is Machine Learning? A Primer for the Epidemiologist written by Justin Lessler and colleagues at Johns Hopkins Bloomberg School of Public Health . #epimethods SER Am J Epidemiology doi.org/10.1093/aje/kw…

#Genetics is a powerful tool for understanding human #ageing New review article in Nature Reviews Genetics by Prof David Melzer & Dr Luigi Ferrucci that I am honoured to be part of doi.org/10.1038/s41576… Short thread below 1/5

A long #journey... begins! Proud to share our new paper Nature Immunology . Marco Di Gioia & co. show how coincident recognition of #PAMP and #DAMP forges #immunometabolism and affects #atherosclerosis ! @Immunoscope Immunometabolism Network Immune Regulation News Human Immunology News nature.com/articles/s4159…

New A happy girl paper: Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study doi.org/10.2337/db18-0… #epigenetics #diabetes

We (with Aviv Regev) want to share with you our preprint scPhere(biorxiv.org/content/10.110…), a deep generative model embedding of single-cell RNA-Seq profiles on hyperspheres and hyperbolic spaces Human Cell Atlas

Economic analysis suggests that cascade screening of ten year-old children for FH and initiation of treatment compared to usual case is cost saving. Via Atherosclerosis sciencedirect.com/science/articl…

what's the role of lipids and lipoproteins in the development of atherosclerotic cardiovascular disease? An informative JAMA clinical update. jamanetwork.com/journals/jama/…

Adam Lubert Cincinnati Children's Heart Institute ACHD Biobank reporting on abnl lipids (↘️HDL, LDL) w/ #Fontan circulation. #ACHD #cardiotwitter FON ahajournals.org/doi/full/10.11…

Do you remember when you joined Twitter? I do! #MyTwitterAnniversary

You: There’s no ChatGPT use case in healthcare Docs: Watch this 👇

Do you remember when you joined Twitter? I do! #MyTwitterAnniversary