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Get ready for myeloma genomic oral session!! Three orals from the team Ciara Freeman Kylee Maclachlan Marcella Kaddoura, MD #ASH24 #mmsm

Last poster session at #ASH. Salome Decombis presenting her work how stromal cells impact leukemia cells sensitivity to NK cells. Has been a great ASH, meeting friends and colleagues all over the world, looking forward next year then! iCAN - Digital Precision Cancer Medicine Medicine and Health, University of Helsinki

Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer nature.com/articles/s4157… This new review covers metabolic dysfunction in CD8 T cells and NK cells in the tumour microenvironment, and therapeutic strategies to restore their anticancer activities

#OnThisDay 1803 Michael Dwyer, who evaded British authorities since 1798 finally surrendered after virtually his entire family was arrested. He was granted free passage to America but the Gov reneged & Dwyer was interred in Kilmainham Gaol& exiled to Australia. #Ireland #History

ST8SIA1 generates ligands for Siglec-7/GD3 inhibiting NK immune surveillance

Amit Agarwal Like using a sledgehammer to crack a nut. CD38 antibodies work in this situation and much simpler and cheaper! nejm.org/doi/10.1056/NE… Dara works too!

Morning after the Storm What's next for the UK? Long rates close to 5%, growth 1% at best & debt/GDP ratio almost 100% = debt spiral on the cards. What can Labour government do to right the ship? Great chat w' Philip Pilkington Mark Carruthers BBC One podcasts.apple.com/ie/podcast/the…

Enticing data for axi-cel in high risk upfront DLBCL in ZUMA-12 3 year followup @BloodJournal 75% 3-year progression free survival Randomised ZUMA-23 data eagerly awaited #lymsm #lymphoma

Spent a great week Moffitt Cancer Center with the great Ciara Freeman on ICE-T cellular immunotherapy service. Impressive program! #CART #myeloma #lymphoma Looking forward to providing this service HSEWestNorthWest Ollscoil na Gaillimhe | University of Galway

Sufficient numbers of functional CD16 pos, DNAM-1 pos NK cells important to derive full benefit from Dara. Important to understand factors that skew NK cells to CD16 neg, DNAM-1 low and how to restore this balance to maximize response to CD38 mAbs

This provides experimental evidence that the clinically employed COX2 inhibitor celecoxib has the potential to prevent AML immune escape from NK-cell killing by reducing their production of PGE. ow.ly/z6tp50Vq7X0 #immunobiologyandimmunotherapy

Please check out our paper published in Nature Medicine on our Phase I trial of AFM13-precomplexed cord blood NK cells in relapsed/refractory CD30+ lymphomas. Led by Dr. Yago Nieto and an outstanding team of coauthors and collaborators, this study marks the first clinical

Creating the best environment to stop cancer cells irishtimes.com/science/2025/0…

By moving the goalposts Ryanair has scored an own goal irishtimes.com/opinion/editor…

Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure | New England Journal of Medicine ⁦Penn Medicine⁩ ⁦⁦Parker Institute for Cancer Immunotherapy⁩ nejm.org/doi/full/10.10…

Targeting Siglec-Sialic Acid Checkpoint to Reverse Immune Dysfunction Mediated by Plasmacytoid Dendritic Cells in Myeloma ashpublications.org/bloodadvances/… #myeloma #glycotime #sialylation #siglec

Right time: stopping multiple myeloma maintenance #mmsm #bmtsm Philip McCarthy Blood Journal ashpublications.org/blood/article/…