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1/9 What else can #MolecularGlues do in addition to #degradation? The Ebert Lab and Fischer Lab, Eric Fischer are proud to present a new mechanism @MolecularGluePolymerization published in nature. Joined forces with Hojong Yoon Jonas Koeppel nature.com/articles/s4158…

We have just uploaded a pre-print to MedRxiv sharing our data on the potential for sera from recipients of currently administered mRNA vaccines to neutralize 10 different circulating strains of #SARSCoV2. Before it posts online, I'd like to put them into context. A thread: 1/12

Vectored ImmunoProphylaxis (VIP) produces broadly neutralizing antibody (VRC07) in humans! I'm incredibly proud to have been able to participate in the development of VIP from the very beginning and am excited to see where this goes next! nature.com/articles/s4159…

We employed the BTB domain of transcription factor BCL6 as small-molecule-controlled reversible oligomerization switch. Led by Lena and my first corresponding author manuscript Cell Reports Methods 1/16 cell.com/cell-reports-m…

1/9 What happens when covalent chemistry meets molecular glue? The Ebert Lab, Fischer Lab, and Gray Lab discovered a trans-labeling covalent mechanism we termed “template-assisted covalent modification” from a new class of DCAF16-based BRD4 degraders.biorxiv.org/content/10.110…

We are happy to share our latest work about the E3 ligase UBR5: Two manuscripts Cell Press! bit.ly/43vM7gJ bit.ly/3DnmRyI The result of fantastic collaborative efforts with the Ebert and Rapé Lab. Thanks to the many contributing authors! #cryoEM #ubiquitin

Excited to share our work Thomä Lab on UBR5 as a common regulator of nuclear hormone receptor degradation. UBR5 competes with co-activators for a conserved site on NRs to regulate ligand dependent transcription on chromatin bit.ly/43vM7gJ Molecular Cell Thanks everyone!

Online Now: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability dlvr.it/SsVCrY

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Check out our final program for TPD Hybrid Meeting, on September 14th, 12-7pm, The event features seminars, panels, flash talks, and networking opportunities. …afarbertargetedproteindegradation.org

Happy to share our article on potential ways to leverage UBR5 activity for targeted protein degradation of transcriptional regulatory proteins. Co-written with E3 ligase expert Asad Taherbhoy Foghorn Therapeutics and inspired by recent exciting UBR5 discoveries! cell.com/trends/pharmac…

What Behavioral and #BiomedicalResearch will this year’s #NIHHighRisk awardees conduct? From #AI and #VirtualReality to #antibioticresistance, see the award-winning, innovative projects early career and seasoned #scientists proposed: go.nih.gov/HRHRpressrelea…

Did you know that the @NIHDirector’s Early Independence Award supports junior #scientists to launch independent careers? Look at how this year’s awardees are “skipping the postdoc” and will pursue their own #biomedical and #BehavioralResearch commonfund.nih.gov/earlyindepende… #NIHHighRisk

Very excited to share that I've been awarded an Early Independence Award to work on nuclear hormone receptors and targeted protein degradation!

Join us tomorrow at 11 am EST for a seminar focusing on UBR5, one of this summer's "hottest" ligases. Featuring speakers Jonathan Tsai, Jacob Aguirre, Kevin Mark, and Durga Kolla. Ebert Lab, Thomä Lab, Rapé Lab …afarbertargetedproteindegradation.org

Targeted protein #degradation: from mechanisms to #clinic. New molecular mechanisms can rapidly be translated - we can learn so much from nature. Great to be able to share this piece with Jonathan Tsai Ben Ebert and Eric Fischer Fischer Lab. #TPD nature.com/articles/s4158…

My lab at MD Anderson Cancer Center is actively seeking motivated individuals (Postdocs, RAs, Scientists) interested in TPD, induced proximity, or small molecule drug discovery. (1/6)