Amyloid and tau have dominated pathophysiological models of dementia aetiology. This preprint identifies 15 novel proteins associated with cognitive decline and dementia. Whitehall II Study #ARIC Joni Lindbohm @gottesman_lab Epi of Ageing Gill Livingston medrxiv.org/content/10.110…

Using 20 years of longitudinal follow-up to look at the association between plasma proteins and rate of #cognitivedecline and #dementia Our preprint at medrxiv.org/content/10.110… Joni Lindbohm Mika Kivimaki

- We identified and replicated 15 plasma proteins associated with cognitive decline rate ⬇️ and dementia - None of these were #amyloid, tau, or neurofilament-related proteins - Currently approved medications affect five of the proteins @amchelsinki Whitehall II Study #proteomics

If anti-amyloid drugs do not prevent clinical dementia, what are the alternatives? This paper identifies 15 new protein targets for #dementia drug development. #Whitehall study #ARIC study @jlindbohm @gill_livingston @gottesman_lab alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

A study identified 15 novel biomarkers that are linked to dementia. These biomarkers are proteins, which predict cognitive decline and increased risk of dementia already 20 years before the disease onset. #dementia #health Joni Lindbohm Mika Kivimaki helsinki.fi/en/news/health…

Large study linked mentally stimulating jobs to –lower levels of proteins that prevent brain cells forming new connections and –a lower risk of #dementia in old age. Mental stimulation may postpone dementia onset by ~1.5y The BMJ #Alzheimers bmj.com/content/374/bm…

Despite previous research, the role of work related mental enrichment in dementia has remained unclear, owing to the small size of study populations. A new study is an important piece of work that addresses these gaps, says Serhiy Dekhtyar ow.ly/vS2550FTzLg

Immune system and blood-brain barrier-wide biomarker analyses provide causal evidence for autoimmunity in dementia medrxiv.org/cgi/content/sh… #medRxiv

Family history has an established role in clinical risk prediction in many diseases, but polygenic risk scores provide a more personalized approach for estimating inherited risk. To understand their dynamics, we systematically examined their interplay: bit.ly/3yPH7aE

#OriginalResearch: Oral glucose tolerance test diagnosed #diabetes were not confirmed by HbA1c during 4 year follow-up. Cases without HbA1c confirmation had similar vascular risk as the diabetes-free population. @whitehall2study Mika Kivimaki #AHAJournals ahajrnls.org/3wFuBJe

Nature Aging: Further evidence that Alzheimer’s is an autoimmune disease. Study also suggests anti-inflammatory drugs, such as methotrexate might prevent dementia. #Triangulation #MendelianRandomization FinnGen Whitehall II Study @JoniLindbohm Samuli Ripatti rdcu.be/cXzOp

This massive study combined evidence for the link between autoimmune diseases and dementia using 6 different big-data approaches. The work was lead by @jlindbohm and Nina Mars with contributions from @pyrysipila, Heiko Runz, Gill Livingston, Ramnik Xavier and many others

🗞Our October issue is out! Read about #autoimmunity in #dementia, #microbiome heterogeneity in aging, #immunosenescence and #COVID-19 vaccination response in #OlderAdults, and more 🎨 cover by Dr. Behnoush Hajian and Lauren Heslop nature.com/nataging/volum…

What do polygenic risk scores (PRS) add to the seemingly simple question about family history (FH)? We explored the interplay of PRS and FH in over 20 common diseases, showing that they have little overlap and provide complementary information. Link: bit.ly/fhprs

Many people are on a path to T2D without knowing, as they are being missed by current screening guidelines - isolated impaired glucose tolerance (iIGT). We identified a novel #proteomics test to help identify them. nature.com/articles/s4159…

Scientists Cambridge University & @berlinnovation used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes. More at mrc-epid.cam.ac.uk/blog/2022/11/1… #type2diabetes #diabetes 🧵(1/n)

#UusiProfiilikuva

Join our new research program at University of Helsinki combatting health inequalities using large-scale epidemiology, genomics, and proteomics! We are looking for: 👨‍🔬 2 Postdoctoral Researchers 🧬 2 Bioinformaticians jobs.helsinki.fi/job/Helsinki-P… jobs.helsinki.fi/job/Helsinki-B…

Many diseases (e.g. #T1D, #rheumatoidarthritis, #IBD, #asthma) impact men and women of reproductive age. In a paper out today Rheumatology & Rheumatology Advances in Practice we asked: What is the impact of immune-mediated diseases on reproductive success and risk of maternal and perinatal outcomes? 📊 An evaluation

NEW Research: Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study. Mika Kivimaki Philipp Frank Markus Jokela Joni Lindbohm Hamilton Oh Epi of Ageing Tony Wyss-Coray Read it here: buff.ly/43bleSM