Another chapter of my PhD work is now online

[Rnf43 & Daam] >10 years of work in four different countries. It is a beautiful story about how Wnt regulators coordinate both canonical and non-canonical Wnt pathways. RZ mutant is tumorigenic, but D12 mutant is not due to lack of NC Wnt signaling. science.org/doi/10.1126/sc…

Unlocking the 'FZD Code': In a molecular showdown, RNF43 and ZNRF3 reveal their unique preferences for depleting Frizzled receptors! Madelon Maurice's lab preprint from Jeroen Bugter discovers RNF43 & ZNRF3 aren't the molecular twins we thought they were. biorxiv.org/content/10.110…

Very excited to share two papers published today in Cell describing stem cell plasticity in CRC. (1/22) cell.com/cell/fulltext/… cell.com/cell/fulltext/…

Excited to share a new Trends in Cancer review: ‘Plastic Persisters: Revival Stem Cells in Colorectal Cancer’. (1/9) cell.com/trends/cancer/…

biorxiv.org/content/10.110… Very excited to share our latest preprint on the 1st functional characterization of OnF reprogramming in CRC, its relevance and therapeutic implications GuccioneLab MarineLab Gaetano Gargiulo Owen Sansom 🏳️‍🌈 Nick barker  #CRC #phenotypicplasticity(1/13)

Congratulations Jeroen Bugter Madelon Maurice lab for successfully defending your PhD thesis this past Tuesday, your colleagues UMCU_CMM wish you all the best in your future career! shorturl.at/lACT5

Hora est! Last tuesday I successfully defended my PhD thesis Utrecht University and received my Dr. title. Looking back at a wonderfull day with friends, family and colleagues. Thanks to Madelon Maurice and everyone involved for giving me this opportunity.

A method for genome scale lncRNA screening using CasRx was developed by Ronald Rad, Juan Montero and colleagues DKFZ, TU München. nature.com/articles/s4159…

Very grateful to be awarded a NWO Rubicon grant! This allows me to continue my postdoctoral work on 'shape-shifting cancer cell' and develop phenotypic CRISPR screening systems TranslaTUM TU München to investigate phenotypic plasticity in colorectal cancer.

Dear Tweeps, the Schewe lab is looking for new colleagues at multiple levels!! For the postdoctoral position in the project shared with Jens Puschhof please apply until the 7th May. We are excited to welcome you! Please RT.

Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: authors.elsevier.com/sd/article/S19… Let’s dive in!

Our paper exploring the different mechanism and selectivity of Frizzled regulation by the presumed paralog tumor suppressor genes RNF43 and ZNRF3 has been published! No time to read? I tried to summarize the main message in a one minute video 👇

Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations Madelon Maurice Jeroen Bugter UMCU_CMM hubs.la/Q02FyGnP0

Looking for PhD students/postdocs for my newly opened lab at the Institute of Human Biology of #Roche in Basel. We work on human lung, liver and gut #organoids. Send email + CV + motivation letter to [email protected] with header #IHB institutehumanbiology.com

USP10 emerges as a unique therapeutic target in APC-truncated #ColorectalCancer 🔬nature.com/articles/s4138… The Diefenbacher Lab #OpenAccess

Great work by Michaela below 👇, discovery of an important new player in oncogenic WNT signaling and potential therapeutic target in APC mutant CRC. Happy to have contributed a tiny part to solving this puzzle 🧩