Our preclinical study on antiretroviral drug repositioning for GBM was published! Our main findings were that certain anti-retroviral drugs have preclinical efficacy and neuropenetrance in GBM. Were translating some of these findings to a clinical trial here UM SVI LAB

Congrats Jay Chandar for winning best medical student research presentation at the FloridaNeuroSociety society meeting this weekend!! UM SVI LAB UM Neurosurgery seetharam deepa

Great time CNS in HOU! We had a great time learning about cutting edge neurosurgery and presenting our brain tumor work! Also congrats to Ray Castro from Sylvester Comprehensive Cancer Center for winning top tumor poster! @JustinTaylorLab UM SVI LAB UM Neurosurgery Jay Chandar Christian K Ramsoomair

Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma biorxiv.org/cgi/content/sh… #biorxiv_cancer

Excited to share our bioRxiv focusing on epigenetic potentiation of immunotherapy for #GBM through viral mimicry! Congrats Jay Chandar Christian K Ramsoomair Deepa Seetharam for their hard work and all our colleagues who contributed to this manuscript! biorxiv.org/content/10.110…

Happy holidays from UM SVI LAB ! Blessed to have such a wonderful motivated and fun team! 🥼Holiday 🍕 party at Casa de Shah. Delicious chocolate cake courtesy of Garcia Nevett Chocolatier de Miami UM Neurosurgery Sylvester Comprehensive Cancer Center seetharam deepa Christian K Ramsoomair Jay Chandar Vaidya Govindarajan

Lot of things to be grateful for this week in the lab! 1. seetharam deepa Jay Chandar got their paper accepted on activating immunotherapy ! 2. Vaidya Govindarajan received a training grant to study GBM exosomes ! 3. Christian K Ramsoomair recent operative pub on virotherapy techniques!

Challenging resection of a large C7 intramedullary hemangioblastoma that had undergone previous biopsy at an outside hospital. Eva Wu Angio Embo - Ty Starke_neurosurgery #Neurosurgery

Thrilled to share our UM SVI LAB work published today in Journal of Clinical Investigation focused on harnessing viral mimicry to activate immunotherapy for #GBM. Thanks to all of my Sylvester Comprehensive Cancer Center UM Neurosurgery colleagues for their invaluable contributions! jci.org/articles/view/…

📢 STARLITE Phase 1 Study. Groundbreaking clinical trial to explore a potential new treatment for unresectable high-grade gliomas. This study aims to assess how these tumors respond to a combination of MR-guided Laser Interstitial Thermal Therapy (LITT) and antiretroviral drugs.

Suppressing Key Protein May Unlock Immunotherapy for Glioblastoma Sylvester Comprehensive Cancer Center Ashish H. Shah Jay Chandar oncodaily.com/insight/gliobl… #OncoDaily #Oncology #Cancer #Health #Medicine #Immunotherapy #MedTwitter #MedEd #MedOnc #MedNews

It’s a dream come true to join this amazing program. Thank you to everyone at UM for this opportunity and for all of your support. Can’t wait for these next 7 years. UM Neurosurgery Allan Levi, MD, PhD Dr. Ricardo J Komotar Ashish H. Shah

Really excited about this awesome group!

Tapping ancient viral DNA in the treatment of glioblastoma! Ashish H. Shah seetharam deepa Jay Chandar & team Miller Medicine show the zinc finger protein ZNF638 activates viral mimicry to promote immune checkpoint inhibition in preclinical models of glioblastoma:

Congrats Christian K Ramsoomair! Excited for your talk at AANS!

Thrilled that we are enrolling for STARLITE phase 1 trial for newly diag. unresectable GBM. We will combine FDA-approved antiretroviral drugs +Laser ablation+SOC. The trial leverages the anticancer effects of ART to target treatment resistant GBM stem cell niche. NCT06428045

Great talk by Christian K Ramsoomair discussing the role of neurosurgeons in brain tumor clinical trials! Christian is a rising superstar in neurosurgery! UM Neurosurgery UM SVI LAB

Congrats to our amazing MD PhD student Christian K Ramsoomair on receiving his NCI F30 grant this week to study pediatric brain tumors! Chris is an rockstar student, scientist and friend! We’re lucky to have him in the UM SVI LAB! He is co-mentored w/ the epigenetic guru Danny Reinberg

A while coming, our NIH R25-funded work on GBM LMD was published exposing the TLR-4 pathway as relevant, and more importantly for me, lays foundations for active cerebrospinal fluid (CSF) exchange studies to make clinical change. Ashish H. Shah

Christian K. Ramsoomair, a fifth-year M.D./Ph.D. student at Miller Medicine, has been awarded the prestigious National Cancer Institute F30 fellowship to advance cancer research at Sylvester. 🙌 Discover how mentorship at Miller School and Sylvester is shaping the future of cancer research: