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Striking similarity between olfactory neuroblastoma model and small cell lung cancer.

Please read, send feedback and retweet link to free full-text work on how a variant cell cycle coordinates differentiation of multi ciliated cells: rdcu.be/dJmnv

Awesome opportunity to work with the rising star of this field in an exciting team!

Why ALK fuses w/ EML4 in lung cancers and not often w/ KIF5B? We never see TMPRSS2-ALK and what's the biology behind? An exciting paper from Chiarle lab led by translocation expert Taek-Chin Cheong. A major step forward to understand the mechanisms of SVs! nature.com/articles/s4146…

Peter Campbell leaves the Sanger Institute at the end of the year to become Quotient's CSO. A mentor and one of my favourite scientists. His foundational, profound and creative contributions to cancer genomics and somatic evolution have truly shaped those fields. [1/7]

We spent two days in the mountains discussing how cancer genomes become such a chaotic and rearranged mess. Thanks to the participants, my fellow co-organizers Isidro Cortes-Ciriano and Titia de Lange, and Forbeck Foundation for bringing us together in Aspen, Colorado!

Wonderful opportunity to interact with the thought leaders of EGFR+ lung cancer. The inaugural meeting in 2019 motivated me to come back to clinic.

Unexpected role of Fanconi anemia pathway in chromothripsis. It’s just incredible learning experience to follow the experimental papers since the initial description of chromothripsis in 2011. Amazing biology.

Fusion variant-specific tumor suppressors in ALK+ lung cancers. SETD2 inactivation conferred a larger impact on tumorigenesis in the context of EML4-ALK v3 (fusing exon 6 of EML4 and exon 20 of ALK) than v1 (e13-e20).

🗣️11 of MSK’s talented scientists & clinicians were selected to appear in an off-Broadway musical called “Lifeline." The show tells the story of the discovery of penicillin, weaving in “superbugs,” romance, & urgent messages about antibiotics, all set to music. A preview ⬇️

So excited to be here with great people who will lead medicine and science! Thanks for Burroughs Wellcome Fund for this opportunity. #CAMS #2024BWF

So glad that I was able to participate in this wonderful multi-year team effort! #SPECIFICancer Cancer Grand Challenges The Mark Foundation for Cancer Research

A beautiful story by Dr. Bishoy M. Faltas on mutational processes in urothelial cancers. Elegant demonstration of fitness benefit of CCND1 ecDNA during chemotherapy. We will learn a lot from WGS of clinical samples re interactions btw treatment and cancer genomes. Congrats to the authors!

1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…

Congratulations to Dr. Mark Kris Memorial Sloan Kettering Cancer Center for being named a Giant of Cancer Care for his many contributions to advancing the field of thoracic oncology! OncLive.com #lcsm onclive.com/view/giants-of… via @onclive