An encouraging report from one of the toughest tumor types. EGFR vIII-directed CAR-T secreting anti-wtEGFR BiTE demonstrating strong on-target activity. Curious if a similar approach targeting EGFR e19/L858R could be helpful for pts w/ EGFR-mutant LUAD with CNS-only progression.

I am fond of my memories in his lab. Best mentor-teacher. Congratulations Peter Park !!

Read this week's Cancer Discovery #ResearchWatch :
Tumor Cell Copy Number Alterations Exhibit Tissue Specificity, summarizing the work of Emma V. Watson, Jake June-Koo Lee, Peter Park, Stephen Elledge et al.
bit.ly/3P6vlAC
BWH Genetics Harvard Medical School UMass Chan Medical School

World Medical Association Stands Firm in Support of Korean Medical Association Amid Government-Induced Crisis
Full Press Release: wma.net/news-post/worl…
대한의사협회
#korea

Here the best team come to solve the mystery of aneuploidy!

NRAS G12C can be targetable by sotorasib, which is five-fold more potent against NRAS G12C compared with KRAS/HRAS G12C. aacrjournals.org/cancerdiscover…

Mutational signature is an essential part of genomics, but small differences in analysis can make a big difference in conclusion. Friends at Peter Park lab Hu Jin and Doga Gulhan tackled several key issues: “flat” signatures, assignment, and validation in their new tool!

I am very proud of our paper on micronucleus formation published today in nature with David Adams and our collaborators!!! Cambridge University UK Dementia Research Institute Wellcome Sanger Institute @TINS

nature.com/articles/s4158…

A new study identifies smoking as a significant contributor to cytokine responses. Its impact on innate immune response goes away with smoking cessation, but the impact on adaptive responses persists, and is associated with DNA methylation changes: nature.com/articles/s4158…

Beyond excited to see this paper out. Most satisfying paper reproducing lung adeno to small-cell transformation in experimental model. Key players: EGFR, TP53, RB1, PIK3CA/PTEN, and MYC. Huge congratulations to Eric Gardner, Ashley Laughney, and the team! science.org/doi/10.1126/sc…

Functional proof of one-step oncogenesis by BRD4-NUT in mice. 100% penetrance from squam epithelium. Cancer types driven by a single massive driver could melt down by effective targeted therapy. Hope one day we see differentiation syndrome in NUT! Cancer Research aacrjournals.org/cancerres/arti…

WGS is the way to go. Excited to see this!

how did long DNA molecules - 100 times longer than those usually sequenced in cancer - help us solve a paradox about BRCA deficiency? read all about in our paper, out in nature today nature.com/articles/s4158… 👇🧵 1/

Essential role of NHEJ in stitching the chromosomal fragments to form chromothripsis.

Very insightful story regarding the sex difference in Xp11 translocation RCC, more common in female. Hibernating Xp fragment where the TFE3 gene resides is waken up by the translocation to autosomes. Sex chroms are rich source of cancer biology. Congrats to Srinivas Viswanathan et al.!