My Favorite Reading Quotes 1. “The reading of all good books is like a conversation with the finest minds of past centuries.” — Descartes 2. “If you only read the books that everyone else is reading, you can only think what everyone else is thinking.” — Haruki Murakami

Honestly, I think this is one of the key clinical takeaways from #IMS23 presented by nizar jacques bahlis… we have to change how we think about treatment and outgrow lines/class-refractory to dynamic and personalized management. #mmsm

Excited to share our work, which shows that T cells targeting a shared neoantigen eliminate acute myeloid leukemia, including cancer stem cells, in vivo in a disease-relevant model Norges forskningsråd European Research Council (ERC) @OsloCancer @UiO_LifeSci Oslounivsykehus nature.com/articles/s4301…

Out in today Nature Medicine, nature.com/articles/s4159… FIH phase 1 trial with Elranatamab in R/R multiple myeloma defining the RP2D. High (ORR 64%) including in patients with high risk cytogenetics and prior anti-BCMA exposure. Responses were durable (DOR 17.1 mod, PFS 11.8 mod).

Kedzierska and colleagues performed single-cell transcriptomic and paired TCRαβ analyses to map epitope-specific CD8+ T cell immunity across the human lifespan ex vivo in newborns, children, adults and older adults. Read it here: rdcu.be/dnT6d nature.com/articles/s4159…

Excited to see this seminal work published today Blood Cancer Discovery led by the talented Paola Neri and @BioBenBarwick on Transcriptional Plasticity Mediating IMiD /CELMoD Resistance in Multiple Myeloma aacrjournals.org/bloodcancerdis… #msmm U Calgary UCalgaryMedicine Charbonneau Cancer Institute

Nizar Bahlis @nbahlis presenting venetoclax-dara-dex elicits durable responses patients with t(11:14) RRMM oral abstract at #ASH2023

Come join us this morning at #ASH23 educational session with the Dr Sham Mailankody and Surbhi Sidana, MD to hear on "How Do We Apply T-Cell Redirection Therapy for Multiple Myeloma? CAR T-Cells and Bispecific Antibodies" Grand Hyatt - Seaport Ballroom ABCD 10:30am - 11:45am

Thousands at #ASH23 eagerly learning from nizar jacques bahlis U Calgary, Dr Sham Mailankody, & Surbhi Sidana, MD. Dr Bahlis is Chair of the Session: How Do We Apply T-Cell Redirection Therapy for Myeloma? CAR T-Cells and Bispecific Antibodies #mmsm Holly Lee Leblay Noémie Gabriele Colasurdo

🙏🏽🙏🏽@MMRF and nizar jacques bahlis. Looking forward to our science together

A subset of CD8 T cells with a terminally exhausted epigenetic profile expressed IFN-γ, granzymes, and perforin in bone marrow Science Immunology Congrats Simone Minnie! Hill Lab Scott Furlan science.org/doi/10.1126/sc…

Kim touched so many lives with her resilience, strength and grace. It was an honour to know her and work with her. Her legacy will live on in all her advocacy. donate.owncancer.ca/fundraiser/551…

Janus kinase (JAK) inhibitors improve antitumor responses Science Magazine Melina Marmarelis Andy Minn E. John Wherry Veronika Bachanova MD Teijaro Lab science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

Original Article: A Novel Anti-CD38 Monoclonal Antibody for Treating Immune Thrombocytopenia nej.md/4b7ZaJ1 #Immunology

We’re at the 21st annual International Myeloma Society meeting Myeloma Society #IMS24 where Dr Nizar Bahlis nizar jacques bahlis presented on genomic and immune signatures in newly diagnosed myeloma. (1/2)

Very excited to share with the myeloma community our latest work on the role of sBCMA and non-T cell factors on the resistance to anti-BCMA TCE ⁦@BloodJournal⁩, work led by ⁦Holly Lee with Paola Neri, Francesco Maura, doi.org/10.1182/blood.…

Our star MD PhD student Dr Holly Lee ⁦Holly Lee⁩ presented at IMS2024 her work on GPRC5D TCE resistance in myeloma

DO NOT MISS at this #ASH24 meeting the VERITAS for the understanding of the acquired resistance mechanisms to anti-BCMA T cell engagers in myeloma #msmm presented by Holly Lee and David Jung. NO MORE ASSUMPTIONS!

sBCMA, surface antigen density, effector-to-target ratio, and TCE dose collectively mediate primary refractoriness to anti-BCMA TCE. ow.ly/V5mT50Uv0QH #immunobiologyandimmunotherapy #lymphoidneoplasia #multiplemyeloma

We just heard from Holly Lee (U Calgary) at #iwGPRC5D2025, who gave a fascinating presentation on clonal evolution and its impact on GPRC5D antigen expression. #MMsm #HemOnc