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For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

New review out in Science Magazine from Jacob Wilde and Kevin Foster, that I had the honor to meddle in as the resident immunologist. What possibilities do hosts have to influence their microbiomes? May contain pandas... Enjoy! science.org/doi/10.1126/sc…

Extremely happy to share that our work on how #antibiotics usage long time ago can impair #gut #mucus function through the #microbiota is now published in Gut Microbes Taylor & Francis Research Insights! tandfonline.com/doi/full/10.10…

Combined with the preprint from Shai Bel, more evidence associating antibiotics usage with disrupted colonic mucus barrier function, worrying stuff...

🚨🚨News from MucinGlycoLab🚨🚨 - New insights into how the intestinal epithelial sialome protects from spontanous colitis, mucositis, and tumor development: We uncover unexpected roles of sialylation in impacting b1 mucus functions, the microbiota, and the stem cell niche!

Now out at #GutMicrobes, our work on Group B Strep in the neonatal intestine tandfonline.com/doi/full/10.10…

Please retweet: Vaishnava Lab MMI_Brown is looking for a post-doctoral fellow. Details of the position and application link: apply.interfolio.com/150992

🦠📷 OUT NOW! Non-canonical start codons in carbohydrate utilisation operons provide context-dependent advantages for commensal E. coli by Yassine Cherrak, Wolf-Dietrich Hardt and colleagues nature.com/articles/s4156…

Microbiota-*independent* negative impact of antibiotics on the colonic mucus barrier, and an interesting link between abx use and susceptibility to #IBD. Nice work from the Bel Lab Science Advances

Exciting collab with Kenya Honda’s lab, out today in nature: A set of microbial strains taken from a human faecal donor can decolonize multidrug-resistant Enterobacteriaceae in the gut, including species associated with #IBD. (1/3) nature.com/articles/s4158…

Spatial Mucinomics 🥳

There's something about this restaurant that doesn't make me want to eat there... but I can't put my finger on it 🙄 #colitolicious

Can we map gut inflammation with ultrasound? Yes, using probiotic biosensors! 🔊 Imagine drinking a "diagnostic yogurt" and getting an ultrasound instead of endoscopy or colonoscopy 😁. Congrats to Marjorie Buss and collaborators on this advance. doi.org/10.1101/2024.0…

Cool 🧊

Some good #popscience exposure for the mighty green stuff (technically transparent, I know I know...) in The New York Times #Mucus: It’s Snot What You Think nytimes.com/2024/10/31/wel…

#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper Cell with Achille Broggi! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OAL7PXqSL5

Check our latest preprint! We've doubled the number of known weberviruses (phages of Klebsiella) and taken a bit of a deep dive into their genomes to better characterise the genus.

🎉 Super excited to announce that our study "Colibactin-driven colon cancer requires adhesin-mediated epithelial binding" is now published in Nature! Huge congratulations to first authors Maude Jans and Magdalena Kolata for their fantastic work! 1/6🧵🎉 nature.com/articles/s4158…