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Glad to share our new cryo-ET work biorxiv.org/content/10.110… I resolved ribosomes to sub-3 Å in cells, realizing the potential we demonstrated. In PTC core where our interested drug Chloramphenicol binds, the local res. hit 2.7 Å, enabling deciphering its MOAs in atomic details.

We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”. Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.

Highly recommended!

I will move to National University of Singapore. Several research assistant, PhD, and postdoc positions are open. I'm interested in nitrogen fixation under changing climates! Please contact me if you are interested! I will attend #ICBPI in Hangzhou. Come and talk to me!

Happy to share our little discovery with Simone Mattei team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out Nature Communications! A collaboration between @medicineUVA, @EMBL, EMBL Imaging Centre, MEMC. Congrats to all authors! nature.com/articles/s4146…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, Jenny Sachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵

🎥 Gregg Popovich spoke at length about the American elections between Kamala Harris and Donald Trump. Full answer 👇

Finally got a cover design through, thanks to Journal of Molecular Biology and especially @Serpell1 "Expanding the protein Universe" sciencedirect.com/science/articl…

Amazing work from my former group in Aarhus University A conserved juxtamembrane motif in plant NFR5 receptors is essential for root nodule symbiosis | PNAS pnas.org/doi/10.1073/pn…

Hibernating ribosomes have a complex social life in starved yeast cells: they assemble into intricate clusters and bind to mitochondria, illustrating how ribosomes hibernate in their natural habitat. More—in this fascinating study by Ahmad Jomaa: nature.com/articles/s4146…

Excited to share our latest work on faba bean-rhizobium interactions rdcu.be/d3i8c headed by Marcela Mendoza-Suárez at Molekylærbiologi - Molecular Biology . A joint PROFABA and N2CROP effort highlighting rhizobium diversity and its impact on plant growth.

Happy to share our latest discovery of the autoactive CNGC15, sufficient to enhance root endosymbiosis in legume and field grown wheat: nature.com/articles/s4158… Thank you to everyone involved! Special shout-out Nicola Cook, G.Gobbato, collaborators @DaveLawson101 , Cristobal Uauy

#MFFL

Time works against the russian regime. A submissive peace deal serves only one-eyed trump and the war criminal dictator putin

The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some are considering changing jobs or leaving the country. Others say them might abandon research altogether.

Zelenskyj is bad-ass and fights for the free world. The other guys with their fine shoes and yachts….not so much theguardian.com/world/live/202…

Francis Collins resigned from NIH yesterday. He rightly pointed out that it's Human Genome Project revolutionized every aspect of biomedical research. He points out that NIH has historically been sens as high priority and non partisan. 1/

The Medicago truncatula LYR4 intracellular domain serves as a scaffold in immunity signaling independent of its phosphorylation activity - Simonsen - New Phytologist - Wiley Online Library nph.onlinelibrary.wiley.com/doi/full/10.11…

Structural basis for size-selective perception of chitin in plants biorxiv.org/content/10.110… #biorxiv_plants