excited to share this lovely #GIpath #GUpath merger study by my colleague chemily

Stumbling upon an excellent resource by the master Andrew Bellizzi 🇺🇦 🙌😇 for neuroendocrine tumors and IHC The Pathologist @GI pathology #pathology

Excited to share our review on renal tumors with defined molecular alterations! journals.sagepub.com/doi/full/10.32…

#GUpath MRI targeted prostate lesional biopsy 🔬: skeletal muscle involvement by prostate cancer should NOT be considered "EPE" (requires tumor invading adipose tissue) but should you still report it? we do in our synoptic summary table (see ref)

1/ Why is Ki-67 called Ki-67? And why am I attaching a photo of this beautiful city to the tweet? If you work in pathology or oncology, you’ve likely come across Ki-67 many times. But where does the name come from? A short 🧵 on the origins, function, and significance of Ki-67.

🔬 AML Classification: WHO 5th vs ICC 🩸🧵 1️⃣ WHO 5th Edition: ✅ AML with defining genetic abnormalities (no blast threshold): •🧬 Fusion: RUNX1::RUNX1T1, CBFB::MYH11, DEK::NUP214, BCR::ABL1, etc. •🧬 Rearrangements: KMT2A, MECOM, NUP98 •🧬 Molecular: NPM1, CEBPA ⚠️ If

Biliary tract biopsy-10 tips to recognize cancer when conventional criteria fail you 1. Dysplasia does not produce a stricture, this finding almost always represent carcinoma 2. Most adenocarcinomas do not elicit desmoplasia when invading the mucosa 3. Abrupt transitions between

TURP for BPH with lymphocytes mimicking prostate signet ring adenocarcinoma oldie but goodie #GUpath reference: ncbi.nlm.nih.gov/pubmed/2430479 excellent recommended recent review by Kiril_T_Can on benign mimickers of prostate cancer: ncbi.nlm.nih.gov/pubmed/29297489

Practical approach to signing out GU pathology cases-Dr.Hirsch Low grade, low volume carcinoma: Active surveillance Intermediate grade, increased volume: Radical prostatectomy (RP), radiation + androgen deprivation therapy (ADT) High grade, variable volume: RP, Radiation +ADT,

Adrenocortical carcinomas-Scoring system No single system has been shown to be completely sensitive or specific in all settings. The Reticulin Algorithm has a more simplified approach (see pic 2) Dr. Mete #USCAP25 #PathX #pathology

while you're better off using a "lymphatic specific" #IHCPath marker if you need to sort out lymphatic vs vascular invasion, often with CD31 the fainter staining pattern is seen in LYMPHATIC invasion ✔️here, #GUpath TURBT with LVI (likely "lymphatic" invasion)

#BSTPath #beautyinthebenign

Common sense approach to prostate cancer, Michelle_Hirsch (Donovan) - a first-time diagnosis or when you're taking a patient out of active surveillance is when pathology matters most! Know the features which transition patients out of AS. 👇 #PathWebinarPearls #GUpath

A review in Endocrine Pathology proposes a new classification system for prostate neuroendocrine neoplasms, aiming to better reflect their biological and clinical heterogeneity, which is crucial for tailored treatment approaches. bit.ly/4laOI8y Endocrine Pathology

Meningioma updates Meningioma with brain invasion -If histologically bland, send for molecular testing. If there is 1p loss and 22q loss and/or NF2 variant, it could classify as grade 2 -Presence of TERT promoter mutations and CDKN2A/2B homozygous deletion classifies a

#USCAP with Dr Dry Lack of fatty component does NOT mean a WDLPS is dedifferentiated -->✨Cellular WDLPS/ALT ✨is non-fatty, acts like WDLPS, exists on broad morph spectrum, and MUST have <5 mits (only distinguishing feature from dediff, for now...)❗️ #PathWebinarPearls

Hepatocellular Carcinoma CDX2 and SATB2 expression does not exclude HCC Use a panel Dr. Chandan #USCAP25 #pathology #PathX

#PathTweetAward #breastpath #molpath

Arginase-1, HepPar1, Glypican-3 Strenghts and limitations Dr. Chandan #USCAP25 #PathX #pathology

This stain comes from these bugs #mucicarmine #cochineal #pathology