Discovery of a new element in a class of enzymes may help inform cancer drug design New Science Signaling study by Newton Lab Tim Baffi newswise.com/articles/disco…

How does #mTORC2 control the activity of AGC #kinases? Using structural studies and analyzing mutants, the Newton Lab discovers that some AGC kinases harbor a conserved TOR interaction motif that enables the phosphorylation of other sites. UC San Diego fcld.ly/8sqwunz

New research shows how the key therapeutic target #mTORC2 shapes the maturation and activities of various enzymes within cells—helping to answer a long-standing controversy in the field of kinase signaling. @SciSignal #Biochemistry fcld.ly/phyi89r

New research shows how mTORC2 shapes the maturation and #phosphorylation of AGC #kinases. The findings help answer a long-standing controversy in kinase signaling and may have implications for the development of mTOR inhibitors. Newton Lab UC San Diego fcld.ly/5dh0u44

Everyone loves a good model: mTORC2 phosphorylates the TOR Interaction Motif to prime AGC kinases for activation. For PKC, this disrupts an inactive dimer to recruit the activating upstream kinase PDK1. Crucial finding is that the hydrophobic motif is an autophosphorylation!

New research shows how the key therapeutic target #mTORC2 shapes the maturation and activities of various enzymes within cells—helping to answer a long-standing controversy in the field of kinase signaling. @SciSignal #Biochemistry fcld.ly/phyi89r

Research shows how mTORC2 shapes the maturation and #phosphorylation of AGC #kinases. The findings help answer a long-standing controversy in kinase signaling and may have implications for the development of mTOR inhibitors. Newton Lab UC San Diego fcld.ly/5dh0u44

I am grateful to receive support from the American Cancer Society for my research on epigenetic determinants of acute myeloid leukemia. I feel fortunate to work with such a great organization as I continue my postdoctoral research at La Jolla Institute Rao Lab. lji.org/news-events/ne…

mTOR Regulation of AGC Kinases: New Twist to an Old Tail "mTORC2 does not directly phosphorylate the hydrophobic motif, rather it converts kinases such as PKC and Akt into a conformation that can ultimately autophosphorylate at the hydrophobic motif." molpharm.aspetjournals.org/content/early/…

Protein Kinase C gamma Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition biorxiv.org/cgi/content/sh… #bioRxiv

Preprint: Protein Kinase C gamma Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition dlvr.it/S2Rs1B

Our latest work shows that SCA14 driver mutations in PKCγ impair autoinhibition with defect inversely correlated with age of onset. Thesis work of UCSD Biomed Sciences PhD Program Caila Pilo Tim Baffi, collaboration with M. Kunkel A. Kornev, Susan Taylor, Kannan Lab ESBG G. Gorrie biorxiv.org/content/10.110…

Awesome graphics for anyone teaching/learning about reversible protein phosphorylation IUBMB @asbmb

Our April issue is online! On the cover - "Time management for #STEMMstudents during the continuing pandemic" by sandra murray JSDavis ProjectStrengthen Dr. Elsie Spencer (she/her/ella) Antentor Othrell Hinton, Jr PhD (A.J. Hinton). cell.com/trends/biochem…

Phosphate on the hydrophobic motif is the glue that holds PKC together – phosphorylation events by mTORC2➡️PDK1➡️autophosphorylation, opposed by phosphatase PHLPP, lead to HM phosphorylation and a PKC ready to safely face the world; review with Tim Baffi sciencedirect.com/science/articl…

Available online - a Review from Tim Baffi and Newton Lab titled "Protein kinase C: release from quarantine by mTORC2". #autophosphorylation #phosphorylation #PKC bit.ly/3j6KKAB

mTORC2, an enigmatic & essential regulator of AGC kinases such as protein kinase C & Akt, could now mark these kinases for maturity by facilitating autophosphorylation of their regulatory C-tails. Newton Lab Tim Baffi #MOL_EditorChoice #MOL #ASPET bit.ly/3Kz1yfl

Read our June issue - Reviews on #CRISPRadaptation (Dipa Sashital), #silentribosomes (@Campbell_RNAlab), tools to study the glycoproteome (on the cover! Mia Huang 黃雪兒), #telomere repair (JK Nandakumar lab), #PKC (Newton Lab), and #insulin signaling (Dave Guertin). bit.ly/3wkGm7e

Don’t miss the latest issue of Science Signaling! Researchers investigate enzyme mutations in spinocerebellar ataxia and connect an adaptor protein to T cell activation. A Review also explores the link between extracellular vesicles and tumor angiogenesis. scim.ag/D