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📢 Exciting milestone! Guy’s and St Thomas’ NHS Foundation Trust has now randomised its 1st and 2nd participants, bringing us to 3 randomisations study-wide! 🎉 Huge thanks to the St Thomas' Hospital team for their hard work and commitment to research! Divaka Perera #BCIS4 #GSTT

Survival better with current medical+ device therapy than STICH-era MT (+/- CABG) if LVEF<35%! ➡️ are lessons from all RCTs with a OMT control arm time-limited? ➡️ is PCI better than CABG (or vice versa)? These two trials can’t answer this. Await STICH3 trials BCIS-4 Trial

Quite a neat study. Stunning differences in medical therapy over the past two decades. REVIVED with older pts but much better outcomes with modern medical therapy Initial impression: CABG would struggle against 2025 med therapy in pts with ischemic LV dys. Will discuss on

An interesting individual pt meta-analysis of BCIS Revived and Stitch trials showing patients treated with contemporary medical therapy have significantly better outcomes than either medically tx pts or those undergoing cabg in stitch trial. Would we still see a survival benefit

Victor Dayan Less-Is-More Cardiologist This study looked at viability as a continuous measure (and as tertiles), expressed as myocardium likely to recover or scar. doi.org/10.1001/jamaca… There was no interaction between the extent of viability and outcomes whether treated by MT or PCI. Appendix has wealth of data

Are pressure-based indices vessel agnostic? Pressure derived indices in the Left Main Amedeo Chiribiri Kevin O'Gallagher Ozan M. Demir @k_desilva Matthew Li Kam Wa Divaka Perera @ukHeartResearch @theBHF #cardiotwitter #AHAJournals ahajrnls.org/3H6YdY0

Bernard De Bruyne Divaka Perera CircInterventions Ozan M. Demir British Heart Foundation PCRonline 🫀 Morton J Kern Carlos Collet MD PhD Mona Tirén Ziad Ali William Fearon Simone Biscaglia Gianluca Campo As Bernard De Bruyne points out, the unequivocal finding from this study is that Pd and all related indices (like FFR iFR) are lower in the LAD than LCX. Whatever the reason, does this matter? YES. If assessed by PW in LCx alone ~ 1 in 4 significant LMCA lesions would be missed

Have you seen the new publication from INOCA International Medical Advisory Board member, Professor Divaka Perera and colleagues? 😃 You can view the full article here - ahajournals.org/doi/10.1161/CI… You can learn more about INOCA here - INOCAInternational.com

British Heart Foundation funds more than 50% of cardiovascular research in the UK, leading to major advances in the fight against heart and circulatory disease. I will be cycling approximately 100km #L2B2025 on 15th June to raise funds for this amazing charity. justgiving.com/team/cardiaccy…

Pressure-Based Physiological Testing Results Diverge Between LAD, LCx tctmd.com/news/pressure-… Ozan M. Demir Divaka Perera British Heart Foundation Cardiovascular and Metabolic Medicine & Sciences TCTMD Caitlin E. Cox CircInterventions William Fearon

Exciting that CHIP-BCIS3 is now in the follow-up phase! The question of elective perc LV unloading to improve patient outcomes in high-risk PCI remains as pertinent now as when this RCT started in 2021. doi.org/10.1161/CIRCIN… Whatever the result, it’ll be worth the wait⏳

Our IPD analysis of REVIVED and STICH is out in print today! Did PCI fail to match CABG, or did medical therapy move the goalposts? Exciting implications for BCIS-4 Trial, which will complete the circle. doi.org/10.1093/eurhea…

Amazing to complete #L2B2025 with so many of different abilities ages and attire, whether they or loved ones have been affected, or they devote their time to fight heart disease, united to help British Heart Foundation do the fantastic work they do! You can still donate- justgiving.com/team/cardiaccy…

A brilliant couple of weeks for our excellent colleague Natalia Briceno at #WexhamCardiology Frimley Health NHS Foundation Trust 💙 FrimleyHealth&CareICS Frimley Excellence!!! Great work Natalia

Congrats to our King's BHF Centre colleague Prof Divaka Perera who completed the London to Brighton Bike Ride yesterday to raise money for British Heart Foundation Divaka has blown past his target of £1,350, but there's still time to donate! Consider giving here: justgiving.com/team/cardiaccy…