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How do blood stem cells protect themselves from burnout whilst fighting an infection? Donal O'Carroll study Journal of Experimental Medicine reveals YTHDF2 protein regulates inflammatory response… Prevents premature aging & allows production healthy blood cells throughout life edin.ac/36hXcGz

The O’Carroll lab is looking for talented postdoctoral research associates to join us in our quest to explore piRNA-directed DNA methylation. elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…

Save the dates! "Noncoding RNAs in Development and Cell Differentiation" at the Weizmann Institute 30/1-2/2/2023. Co-organized with Oded Rechavi Luisa Cochella Donal O'Carroll. We promise great science 🧪, yummy food 🍢, and best-in-class weather in the winter☀️. Details to follow ...

Great collaboration, a long project going as back as 2014. My lab with help of Czech Centre for Phenogenomics at Institute of Molecular Genetics & Donal O'Carroll lab studied mutant mice and Richard Stefl's lab CEITEC solved cryo-EM structures. Richard's not on Twitter but KarelK77 is.

A time and single-cell resolved model of hematopoiesis: tinyurl.com/2s3vhr8r. With Kamil R Kranc and Donal O'Carroll groups, we have generated a new model of hematopoiesis, fit for the single cell genomics era, building on Fabian Theis group tinyurl.com/ywpxtrum. Cambridge Stem Cell Institute

Training the next generation of Interdiciplinary Scientists. Applications for the 2023 Wellcome 4 year PhD programme in Integrated Cell Mechanisms (iCM) are now open! Join the next cohort on this innovative PhD Programme. For more info see wcb.ed.ac.uk/iCMPhD #phd #phdlife

Our #CRU326 member & #clinician #scientist Margot Wyrwoll was granted the @DFG_public 'Walter Benjamin Fellowship' for joining the lab of Donal O'Carroll in Edinburgh. Here, she will be for working on piRNA-mediated #transposon silencing - what a great opportunity!

Our best paper just came out. Fantastic collaboration w. Richard Stefl CEITEC, Czech Centre for Phenogenomics & Donal O'Carroll, thanks to everyone involved. Congrats to ZamoreLabUMass & Korostelev Lab on great D.m. Dicer-1 stuff in the same issue. miRNA Dicers differ! cell.com/molecular-cell…

A great first day as a new Group Leader & Centre Director The ICR presenting our work on targeting mRNA modifications in AML at the Keystone RNA modifications symposium. Looking forward to setting up the new lab when I get back to London! #KSRNAMod24

Interested in understanding the dynamics of hematopoietic homeostasis, take a look at our freshly published collaborative study: authors.elsevier.com/sd/article/S19… Well done to all the authors. It was fantastic to collaborate with the Bertie Gottgens and Kamil R Kranc labs.

Online Now: C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line dlvr.it/T2l9SR

Discovery of a pair of genes that work in perfect harmony to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility Study by Donal O'Carroll & Ansgar Zoch in Molecular Cell ➡️ edin.ac/4bwHpER

40 years ago today!

Delighted to share our new work in Nature Cancer in collaboration with Schofield Group led by Hannah Lawson & James Holt-Martyn. We found that HIF hydroxylases are potent therapeutic targets in AML. The ICR. nature.com/articles/s4301…. 1/4

nature.com/articles/s4146… Delighted we could participate in this amazing study. It shows that the piRNA pathway is central to supporting human male fertility and transposon silencing .

Interested in piRNAs and transposon DNA methylation? Our new collaborative work revels a key mechanism underpinning the precision of piRNA-guided LINE1 methylation. Congratulation to all the authors! nature.com/articles/s4158…

Over the moon to finally share my PhD work with you 🎉 We found that the chromatin reader SPIN1 is essential in transposon control and ensure the precision of DNA methylation. It was such a joy working on it, I hope you enjoy the read! nature.com/articles/s4158…

Congratulations to Donal O'Carroll who has been elected as a Fellow of the @RoyalSociety 🌟 His research has led to insights into fertility & the complex mechanisms that ensure genetic information is protected as it passes from one generation to the next ➡️edin.ac/43oQUmj