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I am very happy to be part of the team and continue to learn about the evolution of clonal organisms . Its also great to see that methods of "classical" species evolution and somatic (cancer) evolution are of mutual benefit Barts and The London, Queen Mary Cancer Research UK UK Research and Innovation Queen Mary University of London Cancer Grand Challenges

Traditionally, the program has been very interesting, consider coming to the nice campus of QMUL in London!

1. Delighted to present work from my time in Andrea Sottoriva's lab, now in Nature Cancer! A big effort also led by Javier Fernández-Mateos and Nick Trahearn. We combined genomics + digital pathology to measure evolution in a prostate cancer (PCa) clinical trial. nature.com/articles/s4301…

Clonal competition in ageing human haematopoiesis and its emerging dynamic fitness landscape. By Nathaniel Mon Pere, Benjamin Werner and Francesco Terenzi mathematical-oncology.org/blog/clonal-co… #MathOnco #CancerEvo #EvolutionaryMedicine

Now online in Cancer Discovery: Disparate Pathways for Extrachromosomal DNA Biogenesis and Genomic DNA Repair - by life, Paul Mischel, Howard Chang and colleagues doi.org/10.1158/2159-8… #ecDNA #eDyNAmic @stanford Cancer Grand Challenges

Is the content under the for you button a reflection of my or elon musks mind? I dont know what i have done receive so much political bs to the point that this option is completely useless

Excited to announce that registration for the 12th IMO workshop on Treatment Toxicity is now open. Held onsite Moffitt Cancer Center Nov 3-Nov 8 #MoffittIMO more details: imo12.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 09/30!

I am happy to share our new preprint led by two briliant junior researchers, Long Wang Long Wang and Christo Morison, on a gene-for-gene model in cancer immune coevolution. biorxiv.org/content/10.110…

Congratulations Alexander Stein . It has some nice advances on our theoretical understanding of somatic genetic heterogeneity in different contexts. Also, anyone that gets through the entire supplement deserves a cooky 🥳.

Very happy this is out. A very original idea by Marius Moeller and WeiniHuang to look at the jump size distributions of fixations of variants in constant populations. This distribution is very rugged with a large tail, suggesting that at times, many variants fix together.

A new preprint on the spatial temporal evolution of ecDNA amplified oncogenes in Glioblastoma. Great joined effort of the labs of Charles Swanton Mischel Lab WeiniHuang Howard Chang us and many others. Special congrats to Imran Noorani and Magnus Haughey

Yet another preprint on the evolutionary dynamics if ecDNA. Elisa Scanu and WeiniHuang developed a very general framework to model multi type/species ecDNAs to investigate when mixed cell states are lost or maintained. One of multiple works to come, congratulations!

Delighted that our new work is out now in pre-print. Want to know more about how extrachromosomal DNA shapes evolution and development of glioblastoma? We combined computational modelling with WGS, DNA-FISH and RNAscope to find out, yielding some unexpected results. Take a look!

We are excited to announce that a 10 year project to gather and analyze veterinary necropsy data to discover cancer prevalence across (292) vertebrate species has finally been published open access in Cancer Discovery @aacr bit.ly/40nCqmH #componc #cancer

Still looking for a PhD? One week to apply for CRUKCOLcentre PhD programme and join our lab Barts Cancer Institute (Queen Mary) to work on exciting new project at the interface of cancer and chromatin biology.

Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.110…

RIP USA (1776 - 2024) Always pretended.

Extra-chromosomal DNA reveals lots of surprising and interesting biology. We have more and more evidence from different directions that it plays a major driving role in about 30% of all cancers and in about 60% of all Glioblastomas. Yet, even more work to come in near future.

I'm looking for PhD students to expand our group at UCSD. If you are interested in the broad area of mathematical / theoretical / computational biology, please get in touch. Biosci application deadline is Nov 20. For more info about our research, see wodarzlab.biosci.ucsd.edu