Cytotoxic T cells (magenta) killing lymphoma cells (cyan) over the course of an hour. Target death seen by “popping” of the nucleus (yellow). Left one struggles; right one kills with ease. Open research question: why do some T cells kill better than others? 3-channel volumes

Elite license plate Salk Institute car park 😮‍💨

For reference: at peak plasma concentration (in the middle of the night), humans have around 300-500 ng of melatonin circulating in their blood So this is like a 20 000X physiological dose 😂

Super excited to have been asked to contribute to SoTA letters. You can find my piece calling for the reclamation of excellence in British universities here: open.substack.com/pub/sotaletter…

. Adam Rochussen, Claire Ma and Gillian Griffiths The CIMR find that CRISPR/Cas9-mediated deletion of Cdc42 in primary T cells triggers transcriptional adaptation, leading to enhanced T cell function. Highlight: journals.biologists.com/jcs/article/13… Article: journals.biologists.com/jcs/article/13…

I used to be a hardcore IIFYM guy. A calorie is a calorie, right? New Nature Medicine paper shows that, even when protein, total carbs, total fat, salt, and fibre are equivalent, a minimally-processed diet outperforms an ultra-processed diet for fat loss over an 8-week RCT.

This is true, but it shouldn’t be true. These are basic life skills that should be acquired from adolescence onwards. It’s a bit of an indictment of the education system that PhD candidates are relatively devoid of these attributes & therefore find a PhD to be a trial by fire.

Trying to read up on γδ T cells and found this review that's over 40,000 words with 748 references 😵‍💫 God gives his toughest battles to his strongest soldiers 🫡

Reminder: LLMs are useful tools for intelligent beings. LLMs are not, themselves, intelligent beings.

I hope the authors suggested reviewers whose work they didn’t cite. 4D chess 😂