We are happy to present the new BRENDA Leducq Website with all information about the project, talks, meetings, and other news #brenda Foundation Leducq brenda-leducq.de/brenda

Super happy to share our new work out in Nature Communications, showing that synaptic changes accelerate amyloid-related tau accumulation and spread in #Alzheimer's disease. Many thanks to Michael Schöll and many others! ISD Research, Göteborgs universitet / University of Gothenburg doi.org/10.1038/s41467…

#OriginalResearch: Proteogenomic data integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis #AHAJournals ahajrnls.org/47une7c

A useful resource on the national prevalence of carotid atherosclerosis in China (>10M individuals) JAMA Network Open 👉 increased cIMT (>1mm): 26% | 93% (!) for >80y 👉 plaque: 21% | 87% (!) for >80y 👉 stenosis: 0.6% | 4% for >80y jamanetwork.com/journals/jaman…

Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo academic.oup.com/brain/article-…

First results from 2,500 individuals from eMERGE, a study developed to test genomic risk assessment at a population level. Important PRS data for 10 diseases on: 👉performance 👉feasibility 👉medical actionability 👉translatability nature.com/articles/s4159…

Age-related decline in brain endothelial cell (BEC) function contributes critically to neurological disease.(…) A study by isd investigators 👉Todorov-Völgyi Katalin Judit González Gallego et al. just published on Nature Aging read more here isd-research.de/isd-research

Very excited to share that our DELiVR method is now open access published @NatureMethods. We created a simple, brain-wide cell analysis deep learning tool, no coding needed! Fiji Plugin makes it accessible to all. nature.com/articles/s4159… by Doris Kaltenecker Rami @moritz_negwer

What honor to host the ISGC workshop, here at the preciousLMU St.-Vinzenz-Haus Munich City Great Keynote Lectures and Scientific Sessions and social activities #strokegenetics strokegenetics.org

The 30th ISGC Workshop is in full swing! Thank you to everyone contributing to talks, posters and vivid discussions 🧠🩸🧬🔬 And a big thank you to our host @rainermpg and the ISD Research 🎉✨️🎊

ISD teams gathered for annual scientific retreat to present their projects and discuss work. There were presentations from Ph.D. students, a poster session, invited speaker talks, and an amazing three minute thesis competition. Dominik Paquet Sarah Jäkel @mgeorgakis1

October 15-17 9th ICAA in Munich, ISD co-organizing 9th Interational Conference on Cerebral Amyloid Angiopathy in Munich. Experts will present latest developments in CAA research ranging from basic research to studies in humans. Sign up now: icaaconference.org/registration-d…

Excited to share our newest work showing that neuroinflammation parallels tau spread in 4R tauopathies, suggesting a key role of microglia in tau progression. Many thanks to Maura Malpetti, @RoemerSeb, Johannes Levin, @GunterHoglinger and MatthiasBrendel doi.org/10.1002/mds.29…

Authors from ISD Research, ZMB and colaborators develop repair approaches to reverse the effects of pathogenic mutations in protease HTRA1. nature.com/articles/s4146…

Finally out today! Very proud of this story: Innate immune memory after Stroke drives remote organ pathology This study was led by superstar-postdoc Alba Simats and X-less Sijia Zhang. Cell cell.com/cell/fulltext/…

Did you ever wonder why the risk for subsequent vascular events is increased after a first stroke or MI? Our answer, out now in nature nature.com/articles/s4158… A story about NETosis, DNA-sensing and inflammasome activation. Spearheaded by Stefan Roth and Jiayu Cao.

ERC Starting Grant 2024 for Anna-Sophia Wahl and her team for studying fundamental principles of neuronal repair after stroke. isd-research.de/isd-research-n…

The ISD co-organized the 9th International Conference on Cerebral Amyloid Angiopathy located at the Kardinal Wendel Haus next to English Garden/Munich. Experts presented latest developments in CAA research ranging from basics in research to studies in humans...

Martin Dichgans among „Highly Cited Researchers 2024” clarivate.com/highly-cited-r… 🙌

Incredibly happy and proud to share our newest work in Science Translational Medicine showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to to first authors Sebastian Roemer-Cassiano and Fabian Wagner! science.org/doi/10.1126/sc… Thread below