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New research from Steph Cragg & colleagues reports that the somata of cholinergic interneurons are in close proximity to astrocyte somata & transient depolarization of astrocytes in mice reversibly regulates ChI excitability via⬇️extracellular calcium nature.com/articles/s4146…

“Whole-Brain Spatial Transcriptional Analysis at Cellular Resolution” by Per Uhlén et al. Science dx.doi.org/10.1126/scienc…

Our new study is out! biorxiv.org/content/10.110… We (Marie Carlén) mapped the mouse PFC using single-unit activity! We recorded ~23,000 neurons across cortical/subcortical regions and profiled spont. firing patterns to reveal what separates the PFC from other brain regions. 1/n

Nature Opponent control of reinforcement by striatal dopamine and serotonin nature.com/articles/s4158…

Nature Neuroscience Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle nature.com/articles/s4159…

Enduring modulation of dorsal raphe nuclei regulates (R,S)-ketamine-mediated resilient stress-coping behavior nature.com/articles/s4138…

Thrilled to announce that our study is finally published in Cell Reports! Huge thanks to our dedicated team, collaborators, reviewers, and the support from Vetenskapsrådet, Wallenbergstiftelserna, and @StratNeuro. Proud moment! 🎉 cell.com/cell-reports/f…

Interested in dopamine regulation? Don’t forget the astrocytes! We’re excited to share our new preprint on astrocyte-dopamine interactions in the dorsal striatum and behavioral state transitions. bioRxiv Neuroscience, McGovern Institute, Ann M. Graybiel biorxiv.org/content/10.110…

Science Advances Dynamic responses of striatal cholinergic interneurons control behavioral flexibility science.org/doi/10.1126/sc…

I'm thrilled to share that my work is now officially available on bioRxiv! biorxiv.org/cgi/content/sh… A sincere and heartfelt thank you to our incredible team, mentors, collaborators, and funders for their unwavering support and invaluable contributions throughout this journey!

Excited to share our new study! We identify Anxa1 neurons as particularly vulnerable in Parkinson’s disease. We also show their crucial role in prodromal-phase bradykinesia and procedural motor learning.

Excited to share our latest manuscript from my previous lab, exploring the neuroanatomical and molecular mechanisms underlying atypical antipsychotics! #p11 , #antipsychotics , #serotonin ,#fUS . nature.com/articles/s4138…

New research from Yan-Feng Zhang Steph Cragg & colleagues finds that striatal cholinergic interneurons can transiently limit the reactivation of dopamine axons (via nicotinic receptors) for subsequent action potentials in dopamine neurons nature.com/articles/s4159…

Yuuge paper on #psychedelics The structural diversity of psychedelic drug actions revealed nature.com/articles/s4146…

Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion nature.com/articles/s4146…

Finally out! We used a translational approach to reveal a conserved role of the superior colliculus–ventral tegmental area pathway in social orienting deficits across species. ⁦Marie Schaer⁩ ⁦Alessandro Contestabile⁩ ⁦Nada Kojovic⁩ nature.com/articles/s4138…

Allosteric modulators of D2 - we're coming for you! Read our latest paper on where allosteric modulators of the D2 dopamine receptors bind - new strategy for treating Parkinson's disease? pubs.acs.org/doi/10.1021/ac…

Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations nature.com/articles/s4146…

Parkinson's disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input biorxiv.org/content/10.110… #biorxiv_neursci

New in Current Biology "Presynaptic and postsynaptic determinants of claustro-cortical connectivity" CLA→ACC projections are highly specific: defined by presynaptic identity, postsynaptic target, and cortical layer. Check it here: sciencedirect.com/science/articl… #Neuroscience #Claustrum