Trying to engineer tRNA??? 🧬 We have a created a roadmap 🗺️ in our newest review. Check it out 👇🏼👇🏼👇🏼👇🏼 links.email.frontiersin.org/ls/click?upn=u…

Discovery of antimicrobial peptides in the global microbiome with machine learning: Cell cell.com/cell/fulltext/…

Mistranslating tRNA variants have anticodon- and sex-specific impacts on Drosophila melanogaster biorxiv.org/content/10.110…

mRNA location and translation rate determine protein targeting to dual destinations - PubMed pubmed.ncbi.nlm.nih.gov/37506697/

How does one #tRNA-mimicking mascRNA from #MALAT1 get one CCA tail and is stable, while menRNA from #NEAT1 receives two marking it for decay? We uncover a #riboswitch-like mechanism where menRNA self-destructs by getting seconds.Ilias Skeparnias NatureStructMolBiol go.nature.com/3WcOGmc

SMYD5 methylation of rpL40 links ribosomal output to gastric cancer | Nature nature.com/articles/s4158…

The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. nature.com/articles/d4158…

Happy (t)RNA day! #RNADay Thank you to our first author baker Vale Valentina Blanco - our terrific guest from Juan Pablo Tosar lab - who orchestrated the baking process.

Nature research paper: The ribosome lowers the entropic penalty of protein folding go.nature.com/4clH1rM

I am very proud of the superstar postdoc Haojun Yang, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer. nature.com/articles/s4158…

How to repurpose a #tRNA enzyme into a global stress sensor? Co-led by Bou-Nader lab, Swati Gaikwad, Soheila Bahmanjah, w/ Alan Hinnebusch lab, in PNASNews, we describe how stress kinase Gcn2 adopts and molds Histidyl-tRNA synthetase as a regulatory hub. bit.ly/3YQbiMk

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…

Single-cell proteomics helped answer a fundamental question in development: The molecule mechanisms of symmetry breaking in early mammalian development. A great collaboration with Zernicka-Goetz Lab led by Aleksandra Petelski & Lisa Iwamoto-Stohl.

We're looking forward to the upcoming RNA Leaders USA Congress. Tevard CEO, Daniel Fisher, will give a presentation on our work to pioneer novel tRNA therapeutics and how our platform is enabling us to advance our pipeline. See the full agenda: bit.ly/3T9n295 #RNALeaders

Preprint alert in collaboration with James Fraser (A$AP J) ! We identify that deleting GidB, a 16S rRNA methyltransferase, acts as an "automatic braking system" for mistranslation! Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA biorxiv.org/content/10.110…

At Tevard, we're devoted to improving the lives of people with severe genetic diseases like Duchenne muscular dystrophy (DMD). In honor of #WorldDuchenneAwarenessDay, learn more about DMD, and see how you can help raise awareness: bit.ly/3qh209B #WDAD24

Highly recommended! PhD students apply

That's what the pluripotent stem cell field has been waiting for. Own cells, reprogrammed to iPSCs; differentiated into insulin-producing cells, and translanted back into patient, effectively curing type-1 diabetes! One patient. One year. But a tremendous proof-of-concept.

The official website for the tRNA2024 Conference has been updated! You can now find the latest presentation schedules, session details, and notification to oral/poster presentation. Stay up to date and plan your presentation: trna2024kanazawa.jp #tRNA2024