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🚗 #CARCellTherapy shows clinical success, but its toxicity, off-target effects, and manufacturing challenges limit widespread adoption. In a new review, the Janson lab from Uppsala universitet provides insights into optimising CAR-cell therapies for durable responses in solid

The immunosuppressive tumor microenvironment formed by many solid tumors, particularly #ColonCancer, limits #TCell infiltration. Nanjing University researchers encapsulated combretastatin A4 in human serum albumin, overcoming the immunosuppression: bit.ly/44qvA1m

⏱️ Final week to enter! Subscribe to one of our 20 immunology or cell biology newsletters before July 18 for a chance to win a personalized lab coat. bit.ly/3YYyzuM

✂️ Drs. Andreas Pavlou, Luca Ghita, and scientists used mice with conditional deletions of the #mitochondrial antiviral-signaling protein, an adaptor for RIG-I-like receptor signaling. 🔗 bit.ly/4f2EExe

🧠 Researchers investigated the feature of methionine metabolism in #gliomas and its relationship with the tumor immune microenvironment. 🔗 bit.ly/4m0bQaD

🧬 Researchers identified effective drug target genes to reduce rheumatoid #arthritis risk through the multi-genome-wide association studies analysis. Postgraduate Medical Journal | bit.ly/46aCzNg

🧫 Investigators suggested that PD-1-positive tumor-infiltrating immune cells score of the tumor nest and tumor necrosis may efficiently predict recurrence in pT1b clear cell renal cell carcinoma. 👉 bit.ly/3GDLM6t

🧫 Scientists at Harvard Medical School found that IL-4 suppressed CD8+ T cell acquisition of an epithelial tissue-resident memory T cell phenotype. Check it out! 👉 Nature Immunology | go.nature.com/3UqRxYg

🔎 Scientists identified CD11c+ CD8+ T cells, an unconventional cytotoxic T cell subset, as significantly enriched and activated in early pregnancy loss cases. 📖 Nature Communications | go.nature.com/40xzUtm

💡 Investigators with Dr. Brian Laight, PhD at Sinclair Cancer Research Institute demonstrated the role of the nonreceptor tyrosine kinase Fes, abundantly expressed in immune cells, as an innate intracellular immune checkpoint. Cancer Research | bit.ly/4m9rj8A

🚦 Researchers suggested that human memory CD8+ T cell cytotoxicity is intricately regulated by environmental cues reflecting tissue location and #antigen specificity. Science Immunology | bit.ly/4lEL7Ri

🌡️ Biomimetic nanoparticles, constructed from macrophage membrane-coated cerium oxide, are developed to scavenge multiple inflammatory mediators for #autoimmune disease management concurrently. ACS Nano | bit.ly/3IRHmJH

TGFβ-mediated signals involving IL-4 and PD-1 enable CD8+ T cells to establish tissue-residence in skin nature.com/articles/s4159… Niro Anandasabapathy nature.com/articles/s4159… Nature Immunology preview by Prlic Lab nature.com/articles/s4159…

🐀 Scientists identified CD4+Notch2+Foxp3lo T cells in the spinal cords of mice with experimental #autoimmune encephalomyelitis, DSS−induced colitis model mice, and patients with #UlcerativeColitis as immune regulatory cells. 🔗 go.nature.com/41cVNOQ

✅ Dr. Beate Kristmann and team at Uniklinikum Tübingen investigated the expression of CD276, an immune checkpoint molecule and promising target antigen for CAR-T therapy in small cell lung cancer, at the RNA and protein level. 👉 bit.ly/4l1Wvpa

📢 The The American Association of Immunologists (AAI) has launched an $8 million emergency funding initiative to support scientists whose immunology-focused NIH funding was terminated or frozen in 2025! 🤩 Learn more about the RESTORE Grant Program: bit.ly/3Hd74Ib

🧪 Scientists introduce an “Immuno-initiator” coated with glioma cell membrane and glucose derivative, for delivering an immune modulator and photosensitizer to evoke potent immune responses against isocitrate dehydrogenase mutant #glioma. 👉 ACS Nano | bit.ly/4lOINHu

🧪 Scientists proposed to adopt a “dual pronged attack” strategy in inhibiting the abnormal proliferation of fibroblast-like synoviocytes, providing a promising platform for the comprehensive treatment of rheumatoid #arthritis. ACS Nano | bit.ly/4l71PYy

💉 Researchers developed a sequential-targeting sonodynamic nanovaccine that avoids circulating macrophage uptake, efficiently crosses the blood–brain barrier, and sequentially targets tumor-associated macrophages. ACS Nano | bit.ly/4mqnOur

💡 Scientists showed that tumor cells expressing protein C receptor dampen #antitumor immunity by promoting the production of interleukin-6, which inhibits the differentiation of T helper 1 cells and suppresses the function of CD8+ T cells. Nature Communications | go.nature.com/45BzZPA