Our latest paper on #cardiac #fibrosis is out today in nature. Congrats to Stanford CVI Stanford Medicine researchers led by @Sangkyun_Cho and Siyeon Rhee. And special thanks to computational scientists Greenstone Biosciences for providing #AI #drugdiscovery. Link: nature.com/articles/s4158…

Dual-Site Targeting by Peptide Inhibitors of the N-Terminal Domain of Hsp90: Mechanism and Design #MolecularDynamics #VirtualScreening pubs.acs.org/doi/10.1021/ac… #JCIM Vol65 Issue10 #compchem

PaCS-Q: Python Toolkits for Path Sampling in MD and QM/MM MD Simulation | JCIM pubs.acs.org/doi/10.1021/ac… JCIM & JCTC Journals #comchem #combiol #qmmm

Hinatulan ng #KorteSuprema na guilty sa simple theft o pagnanakaw ang mga manager ng isang pizza restaurant dahil sa pagbulsa ng mga service charge na dapat sana ay ibinahagi sa kanilang mga kapwa empleyado. Sa isang Desisyon na isinulat ni Associate Justice Antonio T. Kho, Jr.,

Undruggable ‘disordered’ proteins become druggable with new AI techniques from David Baker. Science Magazine science.org/doi/10.1126/sc…

Quantum Mechanics/Molecular Mechanics Simulations Distinguish Insulin-Regulated Aminopeptidase Substrate (Oxytocin) and Inhibitor (Angiotensin IV) and Reveal Determinants of Activity and Inhibition pubs.acs.org/doi/10.1021/ac… Adrian Mulholland #JCIM Vol65 Issue12 #compchem

science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

📌 Peptides as a Leading Class Therapeutic Agents: Future and Challenges 🔗sciencedirect.com/science/articl… 🌐 #CRBIOTECH #INPST #Ozempic

Proteins aren't static; why should our designs be? 🔄 🧬 DynamicMPNN trained on pairs of structures, crafting sequences that snap between states (+13% RMSD >ProteinMPNN on 94‑proteins) What's the most exciting application? metamorphic enzymes, transporters, or hinges?? #AI4Bio

Another month, another insane protein design paper from the Baker Lab. This time: Designing binders for intrinsically disordered regions, a common & important component of proteins we care about, with the help of a diffusion model In nature last week

🏐 LINKS AUG 08 🇵🇭 TIME: 🌎 SEA VLEAGUE (W) 🇹🇭 THA vs 🇮🇩 INA - 05:00PM r.cakeo3.rocks/truc-tiep/indo… dzritv.com/sport/snooker bingouy3h.0uhdworryvdet57alive.shop/volleyball/sea… 🇻🇳 VIE vs 🇵🇭 PHI - 08:00PM r.cakeo3.rocks/truc-tiep/viet… dzritv.com/sport/snooker en7.sportplus.live/volleyball/ bingouy3h.0uhdworryvdet57alive.shop/volleyball/sea…

Chemputation of Peptides: nature.com/articles/s4146…

If you’re learning AI/ML, there’s one book that explains it better than most courses I’ve taken. It’s called: AI and Machine Learning for Coders. Highly recommend adding it to your reading list. I have it in PDF. I’ll let you figure out how to get it :)

Petition for jose marie viceral to guest on Christian Esguerra's Facts First! Someone, connect them please! 😁

New Video Series: Statistics & Data Analysis! youtube.com/watch?v=QIXUTs… 35 videos, 10 hours: Random sampling, Central limit theorem, Distribution estimation, Method of moments, Maximum likelihood estimation, Hypothesis testing, Monte Carlo sampling, Bayesian statistics, and more!

TV5 reports that President Marcos has picked former Associate Justices Antonio Carpio and Estela Perlas-Bernabe for the Independent Commission that will investigate corruption issues. The Commission will have 3 to 4 seats. DeusXMachina Ronan Quing

#HighlightOfTheWeek DynamiSpectra, a python package for analysis of molecular dynamics simulations. #compchem pubs.acs.org/doi/10.1021/ac…

JUST IN: Sandiganbayan junks the bid of Senator Jinggoy Estrada to dismiss the 11 counts of graft charges filed against him, among others, in connection with the alleged funneling of P183 million of his Priority Development Assistance Fund/pork barrel fund to Napoles-owned NGOs.

sports are political!!!!!

Whats up payns