G Curigliano MD PhD: DB06 novel LBA session #ASCO24. 60% in TPC received cape. Med FU 18 mo. 3% bone only. Most CDKi preTx. PFS HR 0.62 HER2 low. OS early. Ultralow HR 0.78 w/wide CI overlap 1. 2+ > 1+. ORR better! Grade 5 ILD 0.7%. New SOC 4 hi risk/visc Mets in HER2 low. OncoAlert