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The best thing my PhD supervisor ever told me was: “Anyone can find a good, positive finding, that’s not the hard part. The hard part is when you figure out what’s next after you don’t get the results you wanted. That’s when you become a scientist”

The prevalence of suboptimal affinity binding sites within enhancers creates a vulnerability in genomes whereby single-nucleotide changes that optimize affinity, even slightly, can be pathogenic. doi.org/10.1038/s41586…

We're thrilled to welcome Dr. Nina Mars (Nina Mars), Dr. Arafath (Rafa) Najumudeen (Arafath (Rafa) Najumudeen) and Dr. Simone Rubinacci (Simone Rubinacci) as the newest FIMM-EMBL Group Leaders HiLIFE_Helsinki University of Helsinki! helsinki.fi/en/hilife-hels…

Act fast: Deadline for applications for our Doctoral Researcher positions is almost here! 🟢2-4 openings as part of the FIMM-EMBL international PhD programme 🟢exciting opportunity to explore and combine different research areas 🟢start in Aug 2024 ▶️jobs.helsinki.fi/job/Helsinki-D…

My department at KTH Royal Institute of Technology SciLifeLab is recruiting an Assistant Professor in computational biology! Fantastic academic environment, top notch infra, colleagues and students, international vibe, Sweden is a lovely place to live. More info 👇 kth.se/lediga-jobb/68…

Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in Genomics England ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9

Join us HiLIFE_Helsinki! Two group leader positions open @UH_Neuro

Inspired by Lior Pachter and team's exploration of scRNA-seq pipelines, we face similar challenges in scATAC-seq, only magnified! After 5 years of tackling these inconsistencies with my advisor @JunhyongKim , Here is a summary (and some solutions😃) 1/n #Genomics #Bioinformatics

The odd sensation of returning to a place that was home. Good morning Cambridge ❤️

As part of the #NORPOD programme Emma Haapaniemi and I are looking for a postdoc interested in transcriptomic profiling of CRISPR-edited cells from patients with rare immunological disorders. Working between @NCMMnews and FIMM HelsinkiUni #singlecell #crispr #genetherapy

I hope one day soon most (if not all) of the time we spend on writing grants get freed for actual research..

Looking for a group leader in functional genomics with focus on computational biology. See details at: careers.humantechnopole.it/o/group-leader…

Do you have the ambition to develop a cutting-edge research programme in fundamental and translational stem cell medicine? reNEW Copenhagen is looking for a new #PI with a focus on human #stemcell #biology! Read the full job ad: shorturl.at/utH7w youtube.com/watch?v=4IhvzU…

The Genome Biology Dept @EMBL is recruiting - independent group leader (PI) position. We are interested in people addressing important Qs in the broad area of Genomics in creative ways - including AI, #ArtificialInteligence #jobs embl.org/jobs/position/… embl.org/jobs/position/…

This recently published figure by Sarah Ancheta et al. is very disturbing and should lead to some deep introspection in the single-cell genomics community (I doubt it will). It demonstrates complete disagreement among 5 widely used "RNA velocity" methods 1/

The next call for HiLIFE_Helsinki TT positions is now open. Come join us at University of Helsinki. One of the best decisions I have made!

Doing good science is 90% finding a science buddy to constantly talk to about the project.

Our spatiotemporal atlas of the human midbrain is finally out! Huge collaborative effort with the UCL Great Ormond Street Institute of Child Health crew: Dimitri Budinger, George Hall and Serena Barral. Huge thanks to all PIs involved: Manju Kurian, Sergi Castellano & Helena Kilpinen ([email protected]) ! doi.org/10.1101/2024.0…

A central mistake in biology was to name genes. This over-simplification made reconciling what is happening on the molecular level a mess - it's not rare to find reports of opposite mechanisms in different contexts, claimed involvement in dozens if not hundreds of different

Last autumn FinnGen hit its target of sampling close to 10% of the Finnish population with more than 500,000 participants. We are happy to announce that the results based on the full cohort are now publicly available for the whole research community: finngen.fi/en/results-bas…