I haven’t heard news about this for a while. Nice one! | EpiScanpy: integrated single-cell epigenomic analysis | Nature Communications nature.com/articles/s4146…

new paper from Swathi R Upadhya on biorxiv 'Experimental reproducibility limits the correlation between mRNA and protein abundances in tumour proteomic profiles' biorxiv.org/content/10.110… Thread:

Metabolic modulation of tumors with engineered bacteria for immunotherapy. Local production of L-arginine by a tumor-colonizing E. coli strain increases anti-tumor T cell responses. #NBThighlight by the Roger Geiger Lab nature.com/articles/s4158…

Cohesin reels genomic DNA into loops in a process called loop extrusion. The lab of Jan-Michael Peters is excited to share their first mechanistic insights into how human #cohesin mediates loop extrusion Cell Press [1/9] cell.com/cell/fulltext/…

We are happy to share our pre-print ‘Building regulatory landscapes: enhancer recruits cohesin to create contact domains, engage CTCF sites and activate distant genes’. (1/n)🧵 doi.org/10.1101/2021.1…

We are very happy to announce the launch of our homepage. Learn all the details about our start-up at detechgene.de

Reactivating PKD2 can cure polycystic kidneys Steve Somlo ⁦@YaleNephFellows⁩ Gene therapy here we go! Renal plasticity revealed through reversal of polycystic kidney disease in mice | ⁦Nature Genetics⁩ nature.com/articles/s4158…

Great to see our recent review on the current knowledge of #RNA-binding proteins in #kidney disease and potential therapeutic implications published online by Nature Reviews Nephrology. Wonderful work, @SisaLeufert and the great team CECAD Cologne Universität zu Köln Uniklinik Köln nature.com/articles/s4158…

(1/n) excited to share our new preprint: We visualize and track a CTCF/cohesin loop live using super-res live-cell imaging. CTCF/cohesin loop is rare (~3-6.5% of time) and very dynamic (~10-30 min lifetime), ruling out models of TADs as stable loops. biorxiv.org/content/10.110…

Very excited to share GRaNIE 👵 and GRaNPA 👴: Tools for Inference and evaluation of enhancer-mediated gene regulatory networks. Thanks to my awesome collaborators from the Judith Zaugg group especially Christian Arnold, Annique Claringbould and Neha Daga.(1/9) bit.ly/3tU0U6U

Congratulations to Lioba Ester for a brilliant thesis defense CECAD Cologne Uniklinik Köln 🎉🥳🍾 !!! Many thanks to Joseph Bonventre and his team for allowing Lioba to enter the world of kidney organoids!

(1/2) First preprint from the lab! We found that PFA fixation can both enhance and diminish LLPS in cells, even causing puncta to artificially appear or disappear. Our work suggests caution in claiming in vivo LLPS based solely on fixed-cell imaging like immunofluorescence.

📢📢📢 Latest and exciting news from @EuroCilia2022 : Maureen Barr Maureen Barr and Shu-Hsien Sheu Shu-Hsien Sheu accepted our invitation 🙂 and complete our list of 23 fantastic invited speakers 👇 cilia2022.de

📢📢📢 EMBO Cilia2022 📢📢📢 Abstract submission deadline extended! New deadline: Sunday, July 17 ! Thanks for sharing your latest results at @EuroCilia2022 #cilia #ciliopathies EMBO

The number of abstracts we received for EMBO Cilia2022 @EuroCilia2022 is overwhelming. Many thanks to all of you out there! 🙏 Dear authors: Please check your 📫for info on how to apply for travel grants generously provided by EMBO . Deadline Aug 3, 2022.

🐙#Podocytes🐙make me break my🐦silence ... 📢📢Preprint from Lioba Ester Inês Cabrita francesca fabretti & our🦛hippo team: NUPs control YAP/TAZ & vice versa biorxiv.org/content/10.110… #KFO329 #FSGS #KidneyDisease #Hippo #Nephrology Uniklinik Köln #CRU329 #Hipposignaling

Forschung zum Anfassen und tolle Vorträge 🙂🙂🙂 CECAD Cologne Uniklinik Köln Universität zu Köln MPI for Biology of Ageing

Ever wondered how transient transcription factor DNA binding can robustly activate transcription? In this new preprint, we find support for one of the possible mechanisms: transcription factors exchange. A 🧵 1/9. biorxiv.org/content/10.110…

Health research leads to the development of new technologies, products & processes which help the life sciences industry become more efficient, competitive & adaptable to changing market demands. Reinvestment in health research will support industrial growth. #ResearchInTrouble