My lab is seeking a postdoctoral fellow in genetically encoded sensors and tools for studying the role of redox imbalance in cancer, neurodegeneration and aging jobRxiv mitojobs Science Careers linkedin.com/posts/valentin…

Review from Juan José Apiz Saab (he/him) on new tools to study how the tumor microenvironment (TME) reprograms tumor resident cells: sciencedirect.com/science/articl… TLDR: TME was a black box but new tools (including interstitial fluid analysis) tell us what is in the TME and how it interacts with cells.

We are looking for a postdoctoral researcher to work in our liver cancer team examining the role of BNIP3 and NIX in hepatic steatosis and liver cancer. Contact me at [email protected] for more information. macleodlab.uchicago.edu

My lab Emory University is seeking a postdoctoral fellow and a research tech to study mitochondrial biology and (immuno)metabolism. These positions will have the opportunity to learn LCMS-metabolomics. Please RT! jobRxiv mitojobs Science Careers United Mitochondrial Disease Foundation Cell Metabolism Am Soc for Mass Spec

Mechanistic studies of redox dysfunction remain challenging due to limited strategies that can perturb redox metabolism in various cellular or organismal backgrounds. Most studies involving impaired redox metabolism have focused on oxidative stress; consequently, less is known

New research from John Coukos Raymond Moellering & UChicago Chemistry colleagues reports the stereospecific conversion of methylglyoxal to l-lactate by #Parkinsons-associated DJ-1 in solution with negligible or no contribution of direct protein deglycation pubs.acs.org/doi/10.1021/ac…

If you want to gain experience in omics the latest technology, then the #metabolomics facility at UChicagoCancerCenter is a great place to join. Reach out to the Metabolomics Core Technical Director, Hardik Shah (Hardik Shah,) for more information. ow.ly/vglJ50Q7tSJ

Just published in nature: Jing Chen, PhD and colleagues UChicagoCancerCenter showed that trans-vaccenic acid (TVA), a nutrient found in beef and dairy, enhances anti-tumor immunity by activating an important immune pathway. ow.ly/xp9K50QapHF #NothingWillStopUs Kunle Odunsi, MD

Excited to share our lab’s new story online in Cell Metabolism today! We show hepatic reductive stress (elevated NADH/NAD+) activates the transcription factor ChREBP in the liver. We think this helps explain longstanding observed metabolic phenotypes with alcohol use, obesity,

My first R01 to develop therapies for #mitochondrialdisease scored a 4th percentile NINDS. Hiring postdoc/tech/staff scientist. Please RT! Mitochondria News Mitochondrial Medicine mitojobs MitoCanada United Mitochondrial Disease Foundation Mito Research Women in Mitochondria Club Mitochondrie CureMITO @mitotalks E-mit

Leveraging our discovery of markers of mitochondrial disease, our collaborative team Mass General Brigham now reports plasma N-lactoyl amino acids and f-MET as markers of sepsis severity and mortality in the ICU. Metabolomics rdcu.be/dBGcC

mtDNA heteroplasmy dynamics are so complex, even paradoxical. To understand why, we combined precise mtDNA editing w/a new method SCI-LITE. In dividing cells, selection (not drift) acts on cell (not intracellular) fitness to shape population heteroplasmy. rdcu.be/dFDCY

Mass spectrometry data re-interpretation Nature Metabolism. #METLIN's 931K molecular stds data was mined at 0eV CE showing >70% LCMS peaks are in-source fragments (ISF). Shifting how small molecule LCMS data is deciphered #metabolomics ACS Analytical Chemistry Journals @MartinGiera nature.com/articles/s4225…

Hi #cancer #metabolism twitter. New review from Guillaume Cognet: science.org/doi/10.1126/sc…. Has long been understood that tumors experience metabolic stress due to nutrient limitation in the tumor microenvironment. 1/7

New! Online now: Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis dlvr.it/TGcnH9

excited to share new work Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency led by Vinod Tiwari, Olivia Sun & Edwin Lopez Gonzalez from my lab, Byungchang Jin Russell Goodman lab, Mark Herman & @Cnspracklen biorxiv.org/cgi/content/sh…

Excited to share our Scintillon Institute Scripps Research latest work “A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt”: biorxiv.org/content/10.110… When we started working with NADH reductive stress (elevated

Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism go.nature.com/4pktc4M