Three cases of Dense Deposit Disease in a day! Extreme diversity in clinical presentation!Case1-16/M nephrotic synd, Case2-39/F proteinuria in 3rd trimester, Case3-58/M RPRF& proteinuria.Note conventional density "hump" in case 3! #PathTwitter #NephTwitter #electronmicroscopy

Sites of diuretic action and sodium absorption in nephron. 🔗pubmed.ncbi.nlm.nih.gov/30600580/ #MedEd #Nephrology #FOAMed AQP2, aquaporin-2; AVP, arginine vasopressin; cAMP, cyclic AMP; eNaC, epithelial sodium channel; HF, heart failure; PKA, protein kinase A

50M presents with abdominal pain and has raised ketones of 2.3. What would you be thinking? Open this thread and I'll share my approach MedTweetorials #MedTwitter #MedStudentTwitter #MedEd #Tweetorial The Clinical Problem Solvers @Grepmeded Manual Of Medicine

Who said that only the #heart can beat?! #Vasomotion in the afferent arteriole in the #kidney. Green is #calcium in vascular smooth muscle cells. #FluorescenceFriday #Leica Leica Microsystems

1/12 A 44 y/o man is admitted with acute abdominal pain, nausea, vomiting, and diarrhea. HR 130, BP 90/52. You walk into the room to meet the patient. What do you notice? This should generate at least one hypothesis.

Big disease, little person: 9 yo M w/ steroid resistant nephrotic syndrome. Surprise: PLA2R positive membranous nephropathy in the youngest patient I've seen so far. EM revealed Stage III (incorporated/resorbing) GBM deposits = been going on for a while. It wasn't minimal change!

#ISNWCN David Jayne talks on #Newer Therapies in #ANCA #Vasculitis Key points: •Renal involvement ➡️ #poorest outcomes •Histol. scores: Berden Mayo histological classification - useful for prognostication •Renal inv driven by circulating ANCA, complement activation 1/7

"Retrospective study of clinical profile of patients with biopsy proven acute interstitial nephritis – 3 year review" by Mythri Shankar 🇮🇳 converted into a #VisualAbstract by our member Mythri Shankar 🇮🇳. Check this and other visual abstracts at the Congress Delegate Bag 🙌🏼

📢LIVE NOW: UPDATES ON IGA NEPHROPATHY #ISNWCN

Thread🧵. If you love nephrology then ANCA vasculitis must be something that definitely excites you. Great session GlomCon today by Kammi Henriksen & Priya Alexander, MD on pathology of crescentic GN. Few pearls🦪🦪 from today's lecture.

1/10. Wat is the most important driver of worsening renal function in #HeartFailure ? Look at #Tweetorial on central hemodynamic derangements in heart failure #Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR

SGLT2 inhibitors for non-diabetic kidney disease ca. 2020 from CKJ Beatriz Fernandez Fernandez Maria Jose Soler Jose Luis Górriz #Nephpearls academic.oup.com/ckj/article/13…

Voclosporin ⚡ Calcineurin inhibitor, does not requiring serum level monitoring ⚡ FDA-approved for LN in combination with MMF and glucocorticoids based on AURORA 1 nephjc.com/news/2021/6/21… #NephJC #NephMadness VAs Dr Priti MD,FASN🇮🇳 (प्रिति)

🤩 #PLA2R Remains superstar against all of the up-and-coming Membranous GN antigens! Used for: ✅ Diagnosis ✅ Deciding whom to treat ✅ Prognosis ✅ Follow-up ✅ Monitoring for remission ✅ Marker in transplant #NephJC #NephMadness @vernisartan

5% of pts in the SHOCK registry had cardiogenic shock w/ SBP>90. Shock is not a BP#, it is a state of circulatory failure leading to diffuse tissue hypoxia>malfunction. Hypotension is not always shock and shock can occur w/o hypotension. ncbi.nlm.nih.gov/pmc/articles/P…

Mutations in more than 50 genes have been identified in hereditary #podocytopathies to date go.nature.com/31KIDcx

#TipsforNephFellows The ratio btwn urine:plasma osm can estimate whether a pt w #hyponatremia is net excreting/retaining free water If Uosm/Posm > 1: ➖ free 💦 clearance/💦 being retained If < 1: ➕ free 💦 clearance/💦 excreted Calculate it here: nephsim.com/calculators/

Case 3: 79 y/o M w/ DM, CKD, now w/ #AKI nephsim.com/case-3-introdu… Why pts may experience "post-obstructive diuresis": -💦🧂 retention, accumulation of solutes (eg urea) -❌ medullary gradient -⏩ tubular flow, ⬇️🧂reabsorption -PG release #FOAMed #POCUS #Nephrology

MUDPILES takes all the fun out of tox ☠️ and acid/base🧪 a 🧵... @nephrotox

18) We thank all the co-authors on these series led by Rose Mary Attieh Yihe Yang Grant Kirby Serena Bagnasco Andrew Moses Mahmoud Abdelaziz, Rimda Samir Gautam, and special thanks to Astrid Weins