A whole lot is going on in the nucleus of TLR4 stimulated macrophages. Distinct chromatin remodeling factors act at distinct loci to mediate inflammation. Kudos to Hargreaves and colleagues on this important study. HargreavesLab Salk Institute cell.com/immunity/fullt…

Our paper on plasma membrane abundance and phagocytosis is out in Science Immunology! Congratulations to ace myeloid mechanobiologist Ben Winer (Ben Winer) and also to our collaborators Orion Weiner (Weiner Lab) and Jason Cyster. science.org/doi/10.1126/sc…

Why are there so few drugs that target innate immune signaling pathways? Maybe bc we know so little about the natural protein interactions (and dynamics) that mediate innate immunity. A bottleneck for drug discovery may be understanding endogenous innate immune cell biology.

THANK YOU!!!! to the AMAZING cell signaling community for a fantastic inaugural Dynamics and Encoding in Cell Signaling FASEB meeting. We look forward to getting together in 2026!

Check out the N&V in Nature Immunology by Inaki Sanz about Rebecca Elsner Mark Shlomchik Lab's recent paper on how B cell intrinsic IL-12 promotes EF and suppresses GC responses via an autocrine positive feedback loop with IFNg. nature.com/articles/s4159…

Please retweet and share with Pittsburgh undergraduates interested in immunology and microbiology!

Excited to share our paper out today in Cell with Tullia Bruno, PhD Vignali Lab! Part of a trio of papers, we show in #Melanoma, anti-PD1+anti-LAG3 therapy modifies CD8 differentiation to promote enhanced effector function tinyurl.com/2ap5w9va

A new publication from our lab: How aberrant mitochondrial DNA synthesis in macrophages affects inflammation and atherosclerosis. rdcu.be/dR2ei by Niranjana Natarajan Jonathan Florentin, and many collaborators- Jishnu Das Sruti Shiva Krithika Rao Yingze Zhang, Sina Tavakoli

Excited to share our study of T cell signaling, where we directed high-content, single-cell genetic screening to uncover how a single adapter protein orchestrates a complex cellular process essential for health. (1/14) biorxiv.org/content/10.110…

Hello folks! With exciting new grants and new projects in our lab, ✨we are hiring!✨ Please share with prospective Ph.D. students and/or postdocs interested in evolution, genetics, and microbes!

In 2014 I joined the fledgling Tumor Microenvironment Center UPMC Hillman Cancer Center w Robert Ferris, MD, PhD and @VignaliLab, taking a holistic view of cancer by unifying faculty interested in a ‘piece’ of its environment (now 7 investigators!). Today, I announce that we are GROWING! 1/

Double champion! Congratulations Sonia. So proud!

What a week with two publications from our lab! Spatial microniches of IL-2 drive lung migratory Th2 cells to allergens in NI & a review on Systems Immunology Approaches to studying T cells in npj Systems Biology. nature.com/articles/s4159…

How good is our understanding of signaling pathways? In this study together w/ Savitski Lab @EMBL, we combine multiple state-of-the-art resources to evaluate signaling pathway inference using phosphoproteomics and kinase-substrate networks tinyurl.com/2n43jsc4

Vote before you go to lab

I hate downloading new apps, but this was a good call. I hope you post your science, good news, and memes on Bluesky soon. Byeeeeee. bsky.app/profile/gottsc…