First Results of NURE-Combo: A Phase II Study of Neoadjuvant Nivolumab and Nab-Paclitaxel, Followed by Postsurgical Adjuvant Nivolumab, for Muscle-Invasive #BladderCancer brnw.ch/21wMC1Y Andrea Necchi #blsm

#ESMO24 HL: Ra223 + Enza > Enza in mCRPC Enza-naive patients with bone mets. However, low clinical practice impact, as now most of the patients do Enza in HSPC phase. Interesting issue on bone protection: denosumab/ZA is a fundamental support for the combination

#ESMO24 HL: interesting preliminary results on PB biomarkers in MIBC. ctDNA clearance after 2 cycles of EV + IO in pCR pts. No clearance in upstaged pts

#ESMO24 HL: preliminary data in 50 pts showing FMT + pembro/axi having impressive activity in ccRCC. Also immature, but promising efficacy data. Bigger trials needed in that field

#ESMO24 HL: Gut microbiome plays a key role in modulating immune system. Increasing evidence that dysbiosis influences IO response and irAE incidence. High fiber diet defitely seem to promote anti-cancer immunity and may improve ICIs

#ESMO24 HL: great presentation by prof. Andrea Necchi on #SunRISe4 results. TAR-200 + cetrelimab achieving 42% pCR and 60% OS in cis-ineligible/refusing MIBC patients. Moving towards new perioperative combinations while waiting ADCs

#ESMO24 HL: inspiring talk by Roberto Ferrara upon pattern of progression to immunotherapy. HPD is rare but letal, and lacks of biomarkers. Mechanism is unknown. A myeloid-mediated effect is a fascinating, yet reasonable hypotesis. Neu and MDSCs characterization may be the key

New data on neoadj IO in #MIBC from #IBCN24 OPTIMUS trial was a multicenter international study including neoadj Retifanlimab arm before RC in cis-ineligible or refusing pts | CD8+ tumor infiltration was the primary endpoint | pT0N0 rate was 40% in line with other neoadj IO

Spots from #NIBIT2024: intriguing talk by Dr. Gabrilovich on myeloid cells in cancer. Neutrophils have distinct features in TME, spleen and BM. Ferroptosis and downregulation of INF by PMN-MDSCs are mechanisms of immunosuppression and putative druggable targets Nibit

After 3 days of fried arancine and pane e panelle here we go with CLL (Cogrossi Laura Lucia) talking about benefit of high-fiber diet on #MM progression. Intriguing insights also on immune system modulation and potential role of SCFAs Laura Cogrossi CellularImmune_lab Nibit

The role of MRI in muscle-invasive bladder cancer | comprehensive overview by our MD student Giovanni Pastorino and the one and only Chiara Mercinelli Università Vita-Salute San Raffaele Ospedale San Raffaele journals.lww.com/co-urology/abs…

❗️OUT NOW❗️ Our review on recent advancement of MRI in MIBC management. It was amazing to dive deep in this intriguing and dynamic topic! Food for thaughts regarding improvement of VI-RADS and machine learning and AI as new tools to aid treatment decision journals.lww.com/co-urology/abs…

One month left #GURetreat24 expopoint.it/?fuseaction=sk… Ospedale San Raffaele Università Vita-Salute San Raffaele Global Society of Rare GU Tumors IBCG Ashish M. Kamat, MD, MBBS Petros Grivas Philippe spiess Shilpa Gupta Yohann Loriot Sumanta K. Pal, MD, FASCO Neeraj Agarwal, MD, FASCO Nazli Dizman Alberto Briganti Alessandro Larcher Brigida Maiorano Chiara Mercinelli Valentina Tateo

Open up the program book for #GURetreat24 & you will see immediately the uniqueness of Andrea Necchi’s meeting - no unnecessary focus on senior faculty bios; instead, 6 pages devoted to fellows, junior faculty & their accomplishments - Nazli Dizman, Tinatin Alaverdashvili Valentina Tateo

👏 At #GUretreat24 Sumanta K. Pal, MD, FASCO masterfully summarizing amazing progress in RCC in only 15 min: ▫️ Emerging biomarkers such as KIM1 ▫️ Novel front line approaches ▫️ Importance of QoL ▫️ Data on IO rechallenge ▫️ Role of microbiome ▫️ Cell therapies Andrea Necchi

Huge work on ICI #rechallenge in #urothelialcarcinoma made by the one and only Brigida Maiorano Ospedale San Raffaele Università Vita-Salute San Raffaele

If you want to know everything about #Tcellengagers in #prostatecancer check out this excellent review by Zeynep Irem Ozay, MD & @chadihc98 💫