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Now open access in NDT PLA2R autoantibodies, a multifaceted biomarker in nephrotic syndrome and membranous nephropathy 🧐 Spec. + sens. of PLA2R-Ab ELISA at levels ≥20 RU/mL, alongside 2nd screening, a biopsy may be unnecessary. ▶️academic.oup.com/ndt/article/do…

In a very large dataset of people with diabetes treated with GLP-1 drugs cf other medications, there were benefits seen for reduced clotting disorders, seizures, neurocognitive disorders (including Alzheimer's), by Ziyad Al-Aly, MD and colleagues Nature Medicine nature.com/articles/s4159…

Now open access in NDT Obinutuzumab for the management of immune-mediated glomerular diseases 🧐Obinutuzumab holds significant potential as a novel first-line therapeutic option for various immune-mediated glomerular diseases ▶️academic.oup.com/ndt/article/do…

🚨 Breaking down the REGENCY trial 🚨 A Phase 3 RCT evaluating obinutuzumab (Obi) in lupus nephritis (LN). Let's dive into the study design, key findings, and the dosing regimens! 🧵⬇️

The GLP-1 receptor agonists (like Ozempic and Mounjaro) are wildly effective weight-loss agents. But are they COST-effective? That's a trickier question. And a new study just out in JAMA Health Forum provides an answer. A resounding "no." (Thread)

A team of UCSF Nephrologists published in JASN a new molecular mechanism  for coordinated regulation of gluconeogenesis and  renal tubule glucose reabsorption. Remarkably, high dietary potassium can bypass the need for insulin signaling with potential implications for diabetes.

In honor of World Preeclampsia Day (ahajrnls.org/3GfN2Mm), we've dedicated a whole issue to the Advance of Pregnancy Hypertension! ahajrnls.org/3Y0ZSnR. Make sure to check it out today!

Calorie restriction is the gold standard for life extension. But it is not without its downsides. In this new review we detail what those are and how they arise. Congrats to co-author Yongqi Wang nature.com/articles/s4157…

Cardio-Kidney Outcomes for Combined versus Monotherapy with Finerenone or SGLT2 Inhibitors in Patients with CKD 🔓doi.org/10.1093/ndt/gf…

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… NEJM

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

clinical relapses of PLA2R-associated membranous nephropathy can occur despite the absence of detectable circulating anti-PLA2R antibodies. A very low anti-PLA2R titer might be enough for a “frail” podocyte KIReports kireports.org/article/S2468-…

Live from the #ERA25

Game changers in kidney vasculitis by Andreas Kronbichler #ERA25 ERA - European Renal Association

CONFIDENCE clearly effective #ERA25

The new Impact Factors are out. Here is a list of some kidney journals: NDT CKJ ERA - European Renal Association

KDIGO is pleased to share the newly published report from its Controversies Conference on Preventing CKD and Maintaining Kidney Health, now available in press in Kidney International. 📄Download the report: kdigo.co/2025-CKD-Preve… 📘 Read the report in KI: kdigo.co/KDIGO-2025-CKD…

Take a look at “Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy,” with Dr. D’Agati from Columbia's Renal Pathology Department as a coauthor jci.org/articles/view/…

🎥Watch Laura Econimo present the CKJ publication: Tolvaptan in Autosomal Dominant Polycystic Kidney Disease ( ADPKD ): A multicenter real life Italian Experience oup.cloud.panopto.eu/Panopto/Pages/…

Anti #Rituximab Antibodies Occurrence and Clinical Outcomes in Patients With Primary #MembranousNephropathy #VisualAbstract by Susan Thanabalasingam kireports.org/article/S2468-… Marco Allinovi