No te pierdas mi último artículo: ¿Desconexión? linkedin.com/pulse/desconex… a través de LinkedIn

No te pierdas mi último artículo: La gente NO se va por dinero linkedin.com/pulse/la-gente… a través de LinkedIn

No te pierdas mi último artículo: Los negocios son Talento linkedin.com/pulse/los-nego… a través de LinkedIn

📣🎉 ¡Con mucha ilusión lanzamos la Edición VII del taller de #DiseñoOrganizacional y #BusinessAgility 📅 21 Abril 2022 ¡Entradas aquí: bit.ly/3H1QwNP! 🙌 Siempre en equipo con SenseTribe 9 brains_es Gerardo Barcia 🎟️ Aprovechad el super descuento del 30% ¡vuelan!

5 of 5 stars to Alexandros by Valerio Massimo Manfredi goodreads.com/review/show/46…

No te pierdas mi último artículo: El dinero son las alas de la gente linkedin.com/pulse/el-diner… a través de LinkedIn

No te pierdas mi último artículo: It's the Collaborations, Stupid! linkedin.com/pulse/its-coll… a través de LinkedIn

5 of 5 stars to El mar, el mar by Iris Murdoch goodreads.com/review/show/49…

Marked as to-read: Slouching Towards Utopia by J. Bradford DeLong goodreads.com/review/show/49…

I’m thrilled to introduce you to the NeuMap! our latest work in nature. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour-de-force 🗺️ Andrés Hidalgo nature.com/articles/s4158…

NeuMap was constructed using scRNA-seq of ~130,000 neutrophils from bone marrow, blood, lung, liver, gut, tumors, infections, and more—spanning health, inflammation, cancer, and development. This isn’t just another dataset—it’s an integrative map of neutrophil states. 🧭

We discovered neutrophils organize into a finite set of 7 transcriptional “hubs,” each linked to specific functions: · PreNeu & Immature hubs · Immune-silent hub (circulating, quiescent) · IFN-response hub (antiviral) · Two immunosuppressive/angiogenic hubs · Ag-presenting hub

These hubs aren’t isolated—they’re connected by maturation and activation trajectories that shift during health, cancer, or inflammation. RNA velocity and timestamp experiments revealed that neutrophils follow preferred paths depending on the physiological context. 🔁

Using multi-omics (DOGMA-seq), we found that key transcription factors like JUNB control angiogenic and immunosuppressive states. Neutrophil-specific deletion of Junb impaired tissue revascularization and blunted tumor growth—validating NeuMap’s predictive power. 🧪

Importantly, NeuMap’s architecture is conserved across sex, genetic background, environmental conditions, AND in humans. We mapped human neutrophil data from healthy, cancer, and lupus samples across 10 different tissues onto NeuMap and identified conserved hubs. 🌍👥

Perhaps most exciting is its potential in diagnostics. By projecting blood neutrophils from 18 different conditions, we created a “barcode” of disease states. This means circulating neutrophils could reveal the host’s pathophysiological state. 🩸✅

In summary: NeuMap redefines how we see neutrophils, not as random variants, but as a structured compartment with defined hubs, trajectories, and conserved principles across biology. This opens new paths for neutrophil-based diagnostics and therapies. 🚀

Grateful to the huge team & collabs Lai Guan NG Soehnlein Lab Udalova Lab - Genomics of Inflammation, D. Quail, L. Walsh, and many more. This was a marathon of single-cell biology, spatial transcriptomics, cytokine screens, genetic models, and computational modeling, all to chart the neutrophil universe.

I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work and our current lines of research! ahidalgolab.com Thank you to Gerardo Barcia for his beautiful design and constant support on building it

Our future of work in a world invaded by Artificial Intelligence open.substack.com/pub/gerardobar…