New review article on the emerging ‘non-canonical’ mechanisms of mTORC1 substrate selectivity and their implication in disease settings - w/ Chiara Di Malta and Andrea Ballabio. cell.com/trends/cell-bi…

We are hiring! A postdoctoral position is available in our lab Tigem Telethon to study nutrient signaling in metabolic diseases. Please email me if interested. More details below ⬇️

Our lab Tigem Telethon retreat 2022

One of the most important nutrient sensing-mTOR papers from our lab. @acangelosi shows that Sestrin is a bona fide leucine sensor in vivo in mice and controls new leucine-sensitive physiology. @sciencemagazine science.org/doi/10.1126/sc…

1/19 Check out the full tweetorial for our new paper in nature - open access! “PI3K drives the de novo synthesis of coenzyme A from vitamin B5” Collaboration between Dibble lab Dibble Lab and Toker lab Alex Toker at BIDMC BIDMC and HMS Harvard Medical School nature.com/articles/s4158…

science.org/doi/10.1126/sc… Excited to share our new work out today in Science Magazine, led by stellar postdoc Regina @hijaishin! We report the discovery of LYCHOS, a candidate cholesterol sensor for the mTORC1 kinase. Below is a brief summary of the story.

Exciting new structural data on the mTORC1-Ragulator-Rags-TFEB mega-complex providing a molecular explanation for the high dependence of TFEB phosphorylation on RagC activation status. Glad to see a long journey coming to an end.

It’s out! Extrodinary work from Rachel Jansen Rachel Jansen is out today in Science Advances Science Advances

mTORC1 led us to lysosomes and in turn to develop LysoIP. In a tour de force of tech development and detective work Monther Abu-Remaileh and Nouf Laqtom take LysoIP in vivo and deorphan the function of the Batten Disease gene CLN3. nature.com/articles/s4158… nature

Our paper is online!! #SignalingProfiler is a novel method that allowed us to discover the key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients nature.com/articles/s4137…

Congratulations to Wonyul on his new study just published in Science. See science.org/doi/10.1126/sc… to learn more about how endosomal lipid signaling reshapes the ER to enable cells to burn fats in mitochondria in response to amino acid starvation and how this relates to disease.

Some cancers are hooked on glutamine, but how do they metabolize this abundant amino acid? I'm happy to share the latest from DeBerardinis Lab in Science Advances in which postdoc Akash Kaushik sought to answer this question using patient-derived tumorgrafts. 1/ science.org/doi/10.1126/sc…

Glad to see this out. New work providing a structural explanation for TFEB strict dependence on RagC activation state. See thread below👇 Congratulations Zhicheng Cui | 崔志成 and Hurley Lab for unveiling this beautiful structure.

Get rid of these ridiculous time scales! Surely selecting for people rushing their careers to fit this mould doesn’t help create a creative, healthy and robust research atmosphere #AcademicTwitter

Another piece of the TFEB regulation has been identified by Marcella Cesana and colleagues from the Andrea Ballabio's lab in collaboration with Diego Medina, Davide Cacchiarelli and the Tigem #BioinformaticCore Read the full article here: journals.plos.org/plosbiology/ar… marcella cesana

Apply to the call and enjoy our team!

There is still time for abstract submission! Please, share! 😊