Wong & @Fogellab report a woman & family with acute dystonia to ondansetron, prochlorperazine, and metoclopramide. #Pharmacogenomic testing revealed the CYP2D6 enzyme *41 allele as the likely cause of the medication-induced dystonia. UCLA Neurology rdcu.be/cu6pS

UCLA Neurology Although dystonia can occur with certain medications, it is often unknown why some people develop this and others do not. In this report we discuss the likely underlying genetic basis for medication-induced dystonia in this family. #pharmacogenetics

Hadjinicolaou & Ngo #SETX confirmed functionally to cause a rapidly progressive early‑onset #neurogenetic disorder w severe polyneuropathy @Fogellab collab w C Bennett Al La Spada & Grace Yoon #ALS4 UCLA Neurology UCLA Health News The Hospital for Sick Children (SickKids) National Ataxia Foundation rdcu.be/cDtVw

Best #Neurogenetics advances of 2021: Thanks to American Academy of Neurology Brent Fogel David Geffen School of Medicine at UCLA for sharing his picks on the UK 100,000 Genomes Project pilot study on WGS and CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis. bit.ly/3tInI9u #NeuroTwitter

At UCLA Health, Dr. Brent Fogel is transforming the future of #Neuroscience by identifying the unique genetics of patients to stop neurological diseases. It's one of many ways the innovative research at UCLA Health is transforming patient care. Click below to learn more.

To close out #BrainAwarenessWeek, we have a thread by Dr. Brent Fogel Brent Fogel on UCLA and neurogenetics! 🧠🧬

The UCLA Neurology Clinical Neurogenomics Research Center helps connect #patients with exciting #research studies such as the development of new biomarkers for #ParkinsonsDisease and related disorders by Drs. Gal Bitan, Brent Fogel, Beate Ritz Beate Ritz, MD,PhD, and Jeff Bronstein.

Dr. Brent Fogel in the UCLA Neurogenetics #Clinic cares for patients with X-linked adrenoleukodystrophy. X-linked adrenoleukodystrophy is the most common leukodystrophy, genetic disorders that damage the white matter of the #brain, affecting nearly 1 of 15,000 people in the US.

Did you know UCLA Neurology has the largest clinical Ataxia Center in the West? #UCLA is also a leader in #research and clinical trials on genetic ataxias thanks to the efforts of Drs. Susan Perlman, Brent Fogel, Jessica Rexach Rexach Lab, and Dan Geschwind Geschwind Lab @ UCLA.

Think about the future of #ataxia therapies. Read "Paving the Way Toward Meaningful Trials in Ataxias: An Ataxia Global Initiative Perspective" …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md… National Ataxia Foundation UCLA Neurology Movement Disorders Journal Ataxia Global Initiative

Brent Fogel discusses how #exome sequencing has advanced care in cerebellar #ataxia Neurology Today National Ataxia Foundation UCLA Neurology #RareDisease journals.lww.com/neurotodayonli…

Dr. Brent Fogel Brent Fogel was quoted in a Neurology Today article on how advances in #genetics #research of the past 20 years have changed our understanding of cerebellar ataxia. uclahealth.org/neurology/dr-b…

Can you guess the diagnosis? Excellent case report by Dr. Molly Fensterwald (with contributions from Drs. Noriko Salamon, Joshua Buyers, Harry Vinters, and Brent Fogel ) UCLA Neurology UCLA Health @AJNR

New! Rafehi et al. identify an intronic FGF14 repeat expansion in adult-onset ataxia bit.ly/3BmiyD3

Read Brent Fogel picks for the Best Advances in Neurogenetics in 2022 in Neurology Today including detection of repeat expansions using genome sequencing and novel genetic interactions between SCA17 & SCA48 UCLA Neurology American Academy of Neurology National Ataxia Foundation

"Alterations in oligodendrocyte transcriptional networks reveal region-specific vulnerabilities to neurological disease" in iScience journal sciencedirect.com/science/articl… Dario Tommasini @rachelgiulia KJ collaboration with Jason Hinman National Ataxia Foundation UCLA Health News UCLA Neurology

Read from @fogellab "multiWGCNA: an R package for deep mining gene co-expression networks in multi-trait expression data" #BMCBioInformatics for study of disease-associated gene networks across time or space bmcbioinformatics.biomedcentral.com/articles/10.11… Dario Tommasini UCLA Neurology UCLA Health News

This iScience journal study with Kathie Ngo and Drs. Jason Hinman and Brent Fogel identifies targetable region-specific vulnerabilities to neurological disease mediated by oligodendrocytes. #neurotwitter sciencedirect.com/science/articl…

Our latest publication highlighting the need for improving patient access to #exome sequencing UCLA Neurology National Ataxia Foundation UCLA Health

"Vanishing White Matter" (VNM) is a type of #leukodystrophy that affects axons in our nervous system. There are currently no approved treatments. Dr. Brent Fogel (Brent Fogel) is looking into establishing a protocol for clinical trials on this disease. pubmed.ncbi.nlm.nih.gov/37592248/