How to ruin a data scientist:

Leaving academia is emotional. There's grief, from losing your identity. Shame, from being perceived as a failure. Overwhelm, from not knowing what to do next. 1/

Is forgetting a bug or a feature? Can you delay it and remember longer? Our 🥶COOLEST paper to date (and our most poetic abstract…) Show LOVE ❤️and please SHARE! Thread (1/N)👇 biorxiv.org/content/10.110…

Happy and super excited to share our discovery of a protein fractal! We unravel the surprisingly simple emergence of these marvellous structures and show it might have even been an accident of evolution. Read the full story here nature.com/articles/s4158… Or just stick around 🧵

The “ORBIT for E. coli” paper is out in Nucleic Acids Research! doi.org/10.1093/nar/gk… **Perform genetics (e.g. deletions) without any PCR / cloning – just transform an oligo!** The paper demonstrates benefits over λ Red & shows how oligos scale to high throughput libraries.

Roundworms have short memories, forgetting new information just two to three hours after learning it. But put them on ice and they don’t forget — until they are returned to room temperature go.nature.com/4aM6I4M

New preprint from the lab: A maternal-effect toxin-antidote element causes larval arrest in C. elegans, by Stefan Zdraljevic et al. biorxiv.org/content/10.110…

Genes commonly express multiple #RNA isoforms. But how to visualise each isoform, how they differ in exonic structure and protein domains, as well as their expression levels from your RNA-seq data? Excited to introduce IsoVis isomix.org/isovis/ doi.org/10.1093/nar/gk… 1/n

Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/

Good stuff. Sequencing proteins by reverse translating them back into DNA, and then sequencing that.

AURA: Automated Universal RNAscope Analysis for high-throughput applications biorxiv.org/cgi/content/sh… #biorxiv_cellbio

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s4156…

My PhD work on harnessing the brain parasite Toxoplasma gondii for protein delivery to the brain is out in Nature Microbiology ! nature.com/articles/s4156…

New WormBook.org chapter! With Nuria Flames Lab and Richard Poole we wrote Neurogenesis in C. elegans, now in Genetics: doi.org/10.1093/geneti… We discuss neuron development specifically, but do have a look if you think about acquisition of cell identity more generally

This is legit.

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

The first main article with Mikayel Aznauryan on the atomic details of eukaryotic translation initiation factor eIF4B, leading to functional investigation from nanoscale to mesoscale. This work focuses on the disordered C-terminus and role in self-assembly. ARNA lab @BordeauxSts

This is great! NIAID News have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

Having trouble receiving strain orders in the EU? Never fear! The European Distribution Hub is here! community.alliancegenome.org/t/european-shi…

Biologists, stop putting UMAP plots in your papers! UMAP is a powerful tool for exploratory data analysis, but without a clear understanding of how it works, it can easily lead to confusion and misinterpretation. Link to Simply Statistics blogpost below.