🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

We have exciting new updates to our schedule for the free TPD in-person event on September 14th! Register on our webpage and see you soon!!

Excited to be part of this terrific team with Stegmaier Lab Scott Armstrong Fischer Lab and Ben Ebert at Dana-Farber !Thank you for the opportunity, Cancer Grand Challenges !

This week in the TPD seminars we are hosting two excellent speakers Kheewoong Baek and Lukas Teoman Henneberg sharing stories from work completed in Prof. Brenda Schulman's lab at Max Planck Institute for Biochemistry ! See you at 11am EST!!!

Don’t miss out on attending the Keystone Targeted Protein Degradation and Proximity Therapeutics, January 21-24, 2024 🧬⛷️👩‍💻 Abstract deadline is October 26. Targeted Protein Degradation  lnkd.in/erkd5Yt4 Proximity Based Therapeutics lnkd.in/evkF59ga

NEWS! I'm excited to share that I'm joining isb_bonn Uniklinik Bonn Rheinische Friedrich-Wilhelms-Universität Bonn ImmunoSensation as a professor to start my LAB! We are open for business and #hiring for #postdoc #tech positions! #NewPI #MoveToGermany #UniBonn #TPD #InducedProximity Please share! nowak-lab.com

Another incredibly fun Harvard Med BCMP retreat - we decided to become the UPS this year!!

We are looking for a postdoctoral research fellow to work with Eric Fischer and myself to pioneer next-generation covalent drug discovery. Please retweet. Apply here: careers.dana-farber.org/jobs/?search_t… Fischer Lab

Great to see this story out - congrats to the team 🎉

Congratulations Kheewoong Baek 👏🎉

Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) Nature Chemical Biology! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/ rdcu.be/dBZKx

Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and Hong Yue and all co-authors on this story! 1/ nature.com/articles/s4158…

Congratulations Franziska Wachter 🎉👏

#AlphaFold can accurately predict PP2A complexes! We solve the structure of #PP2A A R5E C complex and show that PP2A phosphatase assembly is independent of the C subunit methylation. Great team with amazing Franziska Wachter Fischer Lab #Xray jbc.org/article/S0021-…

We are looking for a couple of Research Technicians to join us in the Fischer Lab! If you enjoy biochemistry/chem bio and are interested in working in a great team exploring degrader induced interactions and degradation reach out or apply: careers.dana-farber.org/job/research-t… Please RT!

Nice DFCI Insight blog post about Sidney Farber Fellow Franziska Wachter who will be conducting her research in Fischer Lab blog.dana-farber.org/insight/2024/0…

Excited to share our story on polymerization in ZBTB transcription factors, which was published in the July 11 issue of Molecular Cell! cell.com/molecular-cell… 1/n

Tune in for a polymerization-themed doubleheader from me, Paul, and Marcin J. Suskiewicz this Thursday at 11am EDT!

A new paper from Benjamin Ebert, Nathanael Gray, Eric Fischer, Fischer Lab, Yen-Der Li, Michelle Ma, and Muhammad Murtaza Hassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology rdcu.be/dPzUW

We keep stumbling on molecular glues, but how can they be made for a pre-selected target? We’ve been working on this question, envisioning a high-throughput chemistry (HTC)-based approach to convert pre-existing ligands into molecular glues. biorxiv.org/content/10.110…

This project was led by postdoc Jamie Shaum and assisted by so many friends (to whom we are most grateful): @georg_e_winter, Fischer Lab, Alessio Ciulli, Scott Armstrong, Alessio Ciulli, Seiya Kitamura, Bruno Melillo, Engle Lab, and Ben Cravatt. (8/end)